Changes in the adherens junctions of human endothelial cells infected with spotted fever group rickettsiae

Gustavo Valbuena, David Walker

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Rickettsiae of the spotted fever group are obligately intracellular bacteria that primarily infect the vascular endothelium, invade adjacent cells propelled by actin polymerization, and cause severe systemic diseases. Endothelial dysfunction and vascular leakage develop as a consequence; this effect is the pathophysiological mechanism that explains most clinical manifestations. Here we report that rickettsial infection of cultured primary human endothelial cells is associated with the formation of gaps in the interendothelial adherens junctions, occurring late during the course of in vitro infections but not early, even when rickettsial loads are significant.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalVirchows Archiv
Volume446
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Adherens Junctions
Rickettsia
Fever
Endothelial Cells
Vascular Endothelium
Infection
Polymerization
Blood Vessels
Actins
Bacteria
In Vitro Techniques

Keywords

  • Adherens junction
  • Endothelial cells
  • Mediterranean spotted fever
  • Rickettsia
  • Rocky Mountain spotted fever
  • Vascular leakage

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Changes in the adherens junctions of human endothelial cells infected with spotted fever group rickettsiae. / Valbuena, Gustavo; Walker, David.

In: Virchows Archiv, Vol. 446, No. 4, 04.2005, p. 379-382.

Research output: Contribution to journalArticle

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