Changes in the viral distribution pattern after the appearance of the novel influenza A H1N1 (pHiNi) virus in influenza-like illness patients in Peru

Victor Alberto Laguna-Torres, Jorge Gómez, Patricia Aguilar, Julia S. Ampuero, Cesar Munayco, Víctor Ocaña, Juan Pérez, María E. Gamero, Juan Carlos Arrasco, Irmia Paz, Edward Chávez, Rollin Cruz, Jaime Chavez, Silvia Mendocilla, Elizabeth Gomez, Juana Antigoni, Sofía Gonzalez, Cesar Tejada, Gerardo Chowell, Tadeusz J. Kochel

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: We describe the temporal variation in viral agents detected in influenza like illness (ILI) patients before and after the appearance of the ongoing pandemic influenza A (H1N1) (pHINI) in Peru between 4-January and 13-July 2009. Methods: At the health centers, one oropharyngeal swab was obtained for viral isolation. From epidemiological week (EW) 1 to 18, at the US Naval Medical Research Center Detachment (NMRCD) in Lima, the specimens were inoculated into four cell lines for virus isolation. In addition, from EW 19 to 28, the specimens were also analyzed by real time-polymerase-chain-reaction (rRT-PCR). Results:We enrolled 2,872 patients: 1,422 cases before the appearance of the pH1N1 virus, and 1,450 during the pandemic. Non-pH1N1 influenza A virus was the predominant viral strain circulating in Peru through (EW) 18, representing 57.8% of the confirmed cases;however, this predominance shifted to pH1N1 (51.5%) from EW 19-28. During this study period, most of pH1N1 cases were diagnosed in the capital city (Lima) followed by other cities including Cusco and Trujillo. In contrast, novel influenza cases were essentially absent in the tropical rain forest (jungle) cities during our study period. The city of Iquitos (Jungle) had the highest number of influenza B cases and only one pH1N1 case. Conclusions: The viral distribution in Peru changed upon the introduction of the pH1N1 virus compared to previous months. Although influenza A viruses continue to be the predominant viral pathogen, the pH1N1 virus predominated over the other influenza A viruses.

Original languageEnglish (US)
Article numbere11719
JournalPLoS One
Volume5
Issue number7
DOIs
StatePublished - 2010
Externally publishedYes

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H1N1 Subtype Influenza A Virus
Peru
Viruses
Influenza A virus
influenza
Human Influenza
viruses
Pandemics
pandemic
biomedical research
tropical rain forests
temporal variation
Biomedical Research
Real-Time Polymerase Chain Reaction
quantitative polymerase chain reaction
cell lines
Polymerase chain reaction
Cell Line
Polymerase Chain Reaction
Pathogens

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Changes in the viral distribution pattern after the appearance of the novel influenza A H1N1 (pHiNi) virus in influenza-like illness patients in Peru. / Laguna-Torres, Victor Alberto; Gómez, Jorge; Aguilar, Patricia; Ampuero, Julia S.; Munayco, Cesar; Ocaña, Víctor; Pérez, Juan; Gamero, María E.; Arrasco, Juan Carlos; Paz, Irmia; Chávez, Edward; Cruz, Rollin; Chavez, Jaime; Mendocilla, Silvia; Gomez, Elizabeth; Antigoni, Juana; Gonzalez, Sofía; Tejada, Cesar; Chowell, Gerardo; Kochel, Tadeusz J.

In: PLoS One, Vol. 5, No. 7, e11719, 2010.

Research output: Contribution to journalArticle

Laguna-Torres, VA, Gómez, J, Aguilar, P, Ampuero, JS, Munayco, C, Ocaña, V, Pérez, J, Gamero, ME, Arrasco, JC, Paz, I, Chávez, E, Cruz, R, Chavez, J, Mendocilla, S, Gomez, E, Antigoni, J, Gonzalez, S, Tejada, C, Chowell, G & Kochel, TJ 2010, 'Changes in the viral distribution pattern after the appearance of the novel influenza A H1N1 (pHiNi) virus in influenza-like illness patients in Peru', PLoS One, vol. 5, no. 7, e11719. https://doi.org/10.1371/journal.pone.0011719
Laguna-Torres, Victor Alberto ; Gómez, Jorge ; Aguilar, Patricia ; Ampuero, Julia S. ; Munayco, Cesar ; Ocaña, Víctor ; Pérez, Juan ; Gamero, María E. ; Arrasco, Juan Carlos ; Paz, Irmia ; Chávez, Edward ; Cruz, Rollin ; Chavez, Jaime ; Mendocilla, Silvia ; Gomez, Elizabeth ; Antigoni, Juana ; Gonzalez, Sofía ; Tejada, Cesar ; Chowell, Gerardo ; Kochel, Tadeusz J. / Changes in the viral distribution pattern after the appearance of the novel influenza A H1N1 (pHiNi) virus in influenza-like illness patients in Peru. In: PLoS One. 2010 ; Vol. 5, No. 7.
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abstract = "Background: We describe the temporal variation in viral agents detected in influenza like illness (ILI) patients before and after the appearance of the ongoing pandemic influenza A (H1N1) (pHINI) in Peru between 4-January and 13-July 2009. Methods: At the health centers, one oropharyngeal swab was obtained for viral isolation. From epidemiological week (EW) 1 to 18, at the US Naval Medical Research Center Detachment (NMRCD) in Lima, the specimens were inoculated into four cell lines for virus isolation. In addition, from EW 19 to 28, the specimens were also analyzed by real time-polymerase-chain-reaction (rRT-PCR). Results:We enrolled 2,872 patients: 1,422 cases before the appearance of the pH1N1 virus, and 1,450 during the pandemic. Non-pH1N1 influenza A virus was the predominant viral strain circulating in Peru through (EW) 18, representing 57.8{\%} of the confirmed cases;however, this predominance shifted to pH1N1 (51.5{\%}) from EW 19-28. During this study period, most of pH1N1 cases were diagnosed in the capital city (Lima) followed by other cities including Cusco and Trujillo. In contrast, novel influenza cases were essentially absent in the tropical rain forest (jungle) cities during our study period. The city of Iquitos (Jungle) had the highest number of influenza B cases and only one pH1N1 case. Conclusions: The viral distribution in Peru changed upon the introduction of the pH1N1 virus compared to previous months. Although influenza A viruses continue to be the predominant viral pathogen, the pH1N1 virus predominated over the other influenza A viruses.",
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T1 - Changes in the viral distribution pattern after the appearance of the novel influenza A H1N1 (pHiNi) virus in influenza-like illness patients in Peru

AU - Laguna-Torres, Victor Alberto

AU - Gómez, Jorge

AU - Aguilar, Patricia

AU - Ampuero, Julia S.

AU - Munayco, Cesar

AU - Ocaña, Víctor

AU - Pérez, Juan

AU - Gamero, María E.

AU - Arrasco, Juan Carlos

AU - Paz, Irmia

AU - Chávez, Edward

AU - Cruz, Rollin

AU - Chavez, Jaime

AU - Mendocilla, Silvia

AU - Gomez, Elizabeth

AU - Antigoni, Juana

AU - Gonzalez, Sofía

AU - Tejada, Cesar

AU - Chowell, Gerardo

AU - Kochel, Tadeusz J.

PY - 2010

Y1 - 2010

N2 - Background: We describe the temporal variation in viral agents detected in influenza like illness (ILI) patients before and after the appearance of the ongoing pandemic influenza A (H1N1) (pHINI) in Peru between 4-January and 13-July 2009. Methods: At the health centers, one oropharyngeal swab was obtained for viral isolation. From epidemiological week (EW) 1 to 18, at the US Naval Medical Research Center Detachment (NMRCD) in Lima, the specimens were inoculated into four cell lines for virus isolation. In addition, from EW 19 to 28, the specimens were also analyzed by real time-polymerase-chain-reaction (rRT-PCR). Results:We enrolled 2,872 patients: 1,422 cases before the appearance of the pH1N1 virus, and 1,450 during the pandemic. Non-pH1N1 influenza A virus was the predominant viral strain circulating in Peru through (EW) 18, representing 57.8% of the confirmed cases;however, this predominance shifted to pH1N1 (51.5%) from EW 19-28. During this study period, most of pH1N1 cases were diagnosed in the capital city (Lima) followed by other cities including Cusco and Trujillo. In contrast, novel influenza cases were essentially absent in the tropical rain forest (jungle) cities during our study period. The city of Iquitos (Jungle) had the highest number of influenza B cases and only one pH1N1 case. Conclusions: The viral distribution in Peru changed upon the introduction of the pH1N1 virus compared to previous months. Although influenza A viruses continue to be the predominant viral pathogen, the pH1N1 virus predominated over the other influenza A viruses.

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