Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat

Chang Hoon Kim, Youngsuk Oh, Jin Mo Chung, Kyungsoon Chung

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The upregulated expression of tetrodotoxin sensitive (TTXs) Na+ channels is thought to play an important role in the development of ectopic discharges (EDs) in axotomized sensory neurons. The present study examined the levels of mRNAs of three subtypes of TTXs Na+ channels, Nav1.7, Nav1.6, and Nax, in the dorsal root ganglion (DRG) after segmental spinal nerve ligation. Following nerve ligation, the level of mRNAs of Nav1.7 and Nav1.6 was decreased, while the Nax mRNA level was increased at 5 days, but not at 1 day, postoperatively compared with the normal levels. Thus, if upregulated expression of TTXs Na+ channels contributes to the generation of EDs in axotomized DRG neurons, Nax is the most likely contributor among the three tested subtypes.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalNeuroscience Letters
Volume323
Issue number2
DOIs
StatePublished - Apr 26 2002

Keywords

  • Ectopic discharge
  • Nerve injury
  • Neuropathic pain
  • Sensory neurons
  • Tetrodotoxin sensitive Na channel

ASJC Scopus subject areas

  • Neuroscience(all)

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