Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat

Chang Hoon Kim; Youngsuk Oh; Jin Mo Chung; Kyungsoon Chung

doi:10.1016/S0304-3940(02)00127-1

Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat

Chang Hoon Kim, Youngsuk Oh, Jin Mo Chung, Kyungsoon Chung

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

The upregulated expression of tetrodotoxin sensitive (TTXs) Na⁺ channels is thought to play an important role in the development of ectopic discharges (EDs) in axotomized sensory neurons. The present study examined the levels of mRNAs of three subtypes of TTXs Na⁺ channels, Na_v1.7, Na_v1.6, and Na_x, in the dorsal root ganglion (DRG) after segmental spinal nerve ligation. Following nerve ligation, the level of mRNAs of Na_v1.7 and Na_v1.6 was decreased, while the Na_x mRNA level was increased at 5 days, but not at 1 day, postoperatively compared with the normal levels. Thus, if upregulated expression of TTXs Na⁺ channels contributes to the generation of EDs in axotomized DRG neurons, Na_x is the most likely contributor among the three tested subtypes.

Original language	English (US)
Pages (from-to)	125-128
Number of pages	4
Journal	Neuroscience Letters
Volume	323
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(02)00127-1
State	Published - Apr 26 2002

Keywords

Ectopic discharge
Nerve injury
Neuropathic pain
Sensory neurons
Tetrodotoxin sensitive Na channel

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(02)00127-1

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title = "Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat",

abstract = "The upregulated expression of tetrodotoxin sensitive (TTXs) Na+ channels is thought to play an important role in the development of ectopic discharges (EDs) in axotomized sensory neurons. The present study examined the levels of mRNAs of three subtypes of TTXs Na+ channels, Nav1.7, Nav1.6, and Nax, in the dorsal root ganglion (DRG) after segmental spinal nerve ligation. Following nerve ligation, the level of mRNAs of Nav1.7 and Nav1.6 was decreased, while the Nax mRNA level was increased at 5 days, but not at 1 day, postoperatively compared with the normal levels. Thus, if upregulated expression of TTXs Na+ channels contributes to the generation of EDs in axotomized DRG neurons, Nax is the most likely contributor among the three tested subtypes.",

keywords = "Ectopic discharge, Nerve injury, Neuropathic pain, Sensory neurons, Tetrodotoxin sensitive Na channel",

author = "Kim, {Chang Hoon} and Youngsuk Oh and Chung, {Jin Mo} and Kyungsoon Chung",

note = "Funding Information: This work was supported by NIH grants NS35057, NS31680, NS11255, and NS34877.",

year = "2002",

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doi = "10.1016/S0304-3940(02)00127-1",

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AU - Kim, Chang Hoon

AU - Oh, Youngsuk

AU - Chung, Jin Mo

AU - Chung, Kyungsoon

N1 - Funding Information: This work was supported by NIH grants NS35057, NS31680, NS11255, and NS34877.

PY - 2002/4/26

Y1 - 2002/4/26

N2 - The upregulated expression of tetrodotoxin sensitive (TTXs) Na+ channels is thought to play an important role in the development of ectopic discharges (EDs) in axotomized sensory neurons. The present study examined the levels of mRNAs of three subtypes of TTXs Na+ channels, Nav1.7, Nav1.6, and Nax, in the dorsal root ganglion (DRG) after segmental spinal nerve ligation. Following nerve ligation, the level of mRNAs of Nav1.7 and Nav1.6 was decreased, while the Nax mRNA level was increased at 5 days, but not at 1 day, postoperatively compared with the normal levels. Thus, if upregulated expression of TTXs Na+ channels contributes to the generation of EDs in axotomized DRG neurons, Nax is the most likely contributor among the three tested subtypes.

AB - The upregulated expression of tetrodotoxin sensitive (TTXs) Na+ channels is thought to play an important role in the development of ectopic discharges (EDs) in axotomized sensory neurons. The present study examined the levels of mRNAs of three subtypes of TTXs Na+ channels, Nav1.7, Nav1.6, and Nax, in the dorsal root ganglion (DRG) after segmental spinal nerve ligation. Following nerve ligation, the level of mRNAs of Nav1.7 and Nav1.6 was decreased, while the Nax mRNA level was increased at 5 days, but not at 1 day, postoperatively compared with the normal levels. Thus, if upregulated expression of TTXs Na+ channels contributes to the generation of EDs in axotomized DRG neurons, Nax is the most likely contributor among the three tested subtypes.

KW - Ectopic discharge

KW - Nerve injury

KW - Neuropathic pain

KW - Sensory neurons

KW - Tetrodotoxin sensitive Na channel

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SN - 0304-3940

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat

Abstract

Keywords

ASJC Scopus subject areas

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