Changes in weight, total fat, percent body fat, and central-to-peripheral fat ratio associated with injectable and oral contraceptive use

Abbey B. Berenson, Mahbubur Rahman

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Objective: The purpose of this study was to determine changes in bodyweight and composition that result from hormonal contraception. Study Design: Dual-energy x-ray absorptiometry was performed at baseline and every 6 months for 3 years for 703 women (African American, 200; white, 247; Hispanic, 256) who were beginning the use of oral contraception (OC; n = 245), depot medroxyprogesterone acetate (DMPA; n = 240), or nonhormonal contraception (NH; n = 218). DMPA discontinuers were observed for up to 2 years to examine the reversibility of the observed changes. Results: Over 36 months, DMPA users increased their weight (+5.1 kg), body fat (+4.1 kg), percent body fat (+3.4%), and central-to-peripheral fat ratio (+0.1) more than OC and NH users (P < .01). OC use did not cause weight gain. After DMPA discontinuation, NH users lost 0.42 kg in 6 months; OC users gained 0.43 kg in 6 months. Conclusion: Bodyweight and fat significantly increase with the use of DMPA. After discontinuation of DMPA, some decrease in bodyweight and fat occurs when NH is used.

Original languageEnglish (US)
Pages (from-to)329.e1-329.e8
JournalAmerican journal of obstetrics and gynecology
Volume200
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • body fat
  • body weight
  • depot medroxyprogesterone acetate
  • oral contraception

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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