Chapter 6 Pyrimidine Damage and Repair

Agus Darwanto, Lynda Ngo, Lawrence C. Sowers

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Pyrimidines are essential to the structure and function of nucleic acids in all organisms. The chemical reactivity of the pyrimidines is therefore a fundamentally important aspect of survival of all organisms. Pyrimidines are subject to endogenous damage through hydrolysis, alkylation and oxidation, and to damage by exogenous environmental molecules. Damage to these important molecules can result in loss of biochemical function and cell toxicity. The damage of pyrimidines in deoxyribonucleic acids (DNA) could have more long-lasting consequences, as many of the pyrimidine lesions are miscoding during DNA replication resulting genetic mutations, and allowing the effects of the damage to be transmitted to future progeny cells. Emerging evidence also suggests that pyrimidines in DNA play a critical role in establishing transcriptional regulation in complex organisms, and that damage to DNA pyrimidines could alter epigenetic programming. Fortunately, repair systems exist in cells that recognize specific damaged structures and facilitate their removal and ultimately DNA repair.

Original languageEnglish (US)
Pages (from-to)153-182
Number of pages30
JournalAdvances in Molecular Toxicology
Volume2
Issue numberC
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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