Characteristics of perimenstrual asthma and its relation to asthma severity and control

Data from the Severe Asthma Research Program

Chitra K. Rao, Charity G. Moore, Eugene Bleecker, William W. Busse, William Calhoun, Mario Castro, Kian Fan Chung, Serpil C. Erzurum, Elliot Israel, Douglas Curran-Everett, Sally E. Wenzel

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Although perimenstrual asthma (PMA) has been associated with severe and difficult-to-control asthma, it remains poorly characterized and understood. The objectives of this study were to identify clinical, demographic, and inflammatory factors associated with PMA and to assess the association of PMA with asthma severity and control. Methods: Women with asthma recruited to the National Heart, Lung, and Blood Institute Severe Asthma Research Program who reported PMA symptoms on a screening questionnaire were analyzed in relation to basic demographics, clinical questionnaire data, immunoinflammatory markers, and physiologic parameters. Univariate comparisons between PMA and non-PMA groups were performed. A severity-adjusted model predicting PMA was created. Additional models addressed the role of PMA in asthma control. Results: Self-identified PMA was reported in 17% of the subjects (n = 92) and associated with higher BMI, lower FVC % predicted, and higher gastroesophageal reflux disease rates. Fifty-two percent of the PMA group met criteria for severe asthma compared with 30% of the non-PMA group. In multivariable analyses controlling for severity, aspirin sensitivity and lower FVC % predicted were associated with the presence of PMA. Furthermore, after controlling for severity and confounders, PMA remained associated with more asthma symptoms and urgent health-care utilization. Conclusions: PMA is common in women with severe asthma and associated with poorly controlled disease. Aspirin sensitivity and lower FVC % predicted are associated with PMA after adjusting for multiple factors, suggesting that alterations in prostaglandins may contribute to this phenotype.

Original languageEnglish (US)
Pages (from-to)984-992
Number of pages9
JournalChest
Volume143
Issue number4
DOIs
StatePublished - Apr 2013

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Asthma
Research
Aspirin
Patient Acceptance of Health Care
Demography
National Heart, Lung, and Blood Institute (U.S.)
Ambulatory Care
Gastroesophageal Reflux
Prostaglandins

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Characteristics of perimenstrual asthma and its relation to asthma severity and control : Data from the Severe Asthma Research Program. / Rao, Chitra K.; Moore, Charity G.; Bleecker, Eugene; Busse, William W.; Calhoun, William; Castro, Mario; Chung, Kian Fan; Erzurum, Serpil C.; Israel, Elliot; Curran-Everett, Douglas; Wenzel, Sally E.

In: Chest, Vol. 143, No. 4, 04.2013, p. 984-992.

Research output: Contribution to journalArticle

Rao, CK, Moore, CG, Bleecker, E, Busse, WW, Calhoun, W, Castro, M, Chung, KF, Erzurum, SC, Israel, E, Curran-Everett, D & Wenzel, SE 2013, 'Characteristics of perimenstrual asthma and its relation to asthma severity and control: Data from the Severe Asthma Research Program', Chest, vol. 143, no. 4, pp. 984-992. https://doi.org/10.1378/chest.12-0973
Rao, Chitra K. ; Moore, Charity G. ; Bleecker, Eugene ; Busse, William W. ; Calhoun, William ; Castro, Mario ; Chung, Kian Fan ; Erzurum, Serpil C. ; Israel, Elliot ; Curran-Everett, Douglas ; Wenzel, Sally E. / Characteristics of perimenstrual asthma and its relation to asthma severity and control : Data from the Severe Asthma Research Program. In: Chest. 2013 ; Vol. 143, No. 4. pp. 984-992.
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abstract = "Background: Although perimenstrual asthma (PMA) has been associated with severe and difficult-to-control asthma, it remains poorly characterized and understood. The objectives of this study were to identify clinical, demographic, and inflammatory factors associated with PMA and to assess the association of PMA with asthma severity and control. Methods: Women with asthma recruited to the National Heart, Lung, and Blood Institute Severe Asthma Research Program who reported PMA symptoms on a screening questionnaire were analyzed in relation to basic demographics, clinical questionnaire data, immunoinflammatory markers, and physiologic parameters. Univariate comparisons between PMA and non-PMA groups were performed. A severity-adjusted model predicting PMA was created. Additional models addressed the role of PMA in asthma control. Results: Self-identified PMA was reported in 17{\%} of the subjects (n = 92) and associated with higher BMI, lower FVC {\%} predicted, and higher gastroesophageal reflux disease rates. Fifty-two percent of the PMA group met criteria for severe asthma compared with 30{\%} of the non-PMA group. In multivariable analyses controlling for severity, aspirin sensitivity and lower FVC {\%} predicted were associated with the presence of PMA. Furthermore, after controlling for severity and confounders, PMA remained associated with more asthma symptoms and urgent health-care utilization. Conclusions: PMA is common in women with severe asthma and associated with poorly controlled disease. Aspirin sensitivity and lower FVC {\%} predicted are associated with PMA after adjusting for multiple factors, suggesting that alterations in prostaglandins may contribute to this phenotype.",
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T2 - Data from the Severe Asthma Research Program

AU - Rao, Chitra K.

AU - Moore, Charity G.

AU - Bleecker, Eugene

AU - Busse, William W.

AU - Calhoun, William

AU - Castro, Mario

AU - Chung, Kian Fan

AU - Erzurum, Serpil C.

AU - Israel, Elliot

AU - Curran-Everett, Douglas

AU - Wenzel, Sally E.

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N2 - Background: Although perimenstrual asthma (PMA) has been associated with severe and difficult-to-control asthma, it remains poorly characterized and understood. The objectives of this study were to identify clinical, demographic, and inflammatory factors associated with PMA and to assess the association of PMA with asthma severity and control. Methods: Women with asthma recruited to the National Heart, Lung, and Blood Institute Severe Asthma Research Program who reported PMA symptoms on a screening questionnaire were analyzed in relation to basic demographics, clinical questionnaire data, immunoinflammatory markers, and physiologic parameters. Univariate comparisons between PMA and non-PMA groups were performed. A severity-adjusted model predicting PMA was created. Additional models addressed the role of PMA in asthma control. Results: Self-identified PMA was reported in 17% of the subjects (n = 92) and associated with higher BMI, lower FVC % predicted, and higher gastroesophageal reflux disease rates. Fifty-two percent of the PMA group met criteria for severe asthma compared with 30% of the non-PMA group. In multivariable analyses controlling for severity, aspirin sensitivity and lower FVC % predicted were associated with the presence of PMA. Furthermore, after controlling for severity and confounders, PMA remained associated with more asthma symptoms and urgent health-care utilization. Conclusions: PMA is common in women with severe asthma and associated with poorly controlled disease. Aspirin sensitivity and lower FVC % predicted are associated with PMA after adjusting for multiple factors, suggesting that alterations in prostaglandins may contribute to this phenotype.

AB - Background: Although perimenstrual asthma (PMA) has been associated with severe and difficult-to-control asthma, it remains poorly characterized and understood. The objectives of this study were to identify clinical, demographic, and inflammatory factors associated with PMA and to assess the association of PMA with asthma severity and control. Methods: Women with asthma recruited to the National Heart, Lung, and Blood Institute Severe Asthma Research Program who reported PMA symptoms on a screening questionnaire were analyzed in relation to basic demographics, clinical questionnaire data, immunoinflammatory markers, and physiologic parameters. Univariate comparisons between PMA and non-PMA groups were performed. A severity-adjusted model predicting PMA was created. Additional models addressed the role of PMA in asthma control. Results: Self-identified PMA was reported in 17% of the subjects (n = 92) and associated with higher BMI, lower FVC % predicted, and higher gastroesophageal reflux disease rates. Fifty-two percent of the PMA group met criteria for severe asthma compared with 30% of the non-PMA group. In multivariable analyses controlling for severity, aspirin sensitivity and lower FVC % predicted were associated with the presence of PMA. Furthermore, after controlling for severity and confounders, PMA remained associated with more asthma symptoms and urgent health-care utilization. Conclusions: PMA is common in women with severe asthma and associated with poorly controlled disease. Aspirin sensitivity and lower FVC % predicted are associated with PMA after adjusting for multiple factors, suggesting that alterations in prostaglandins may contribute to this phenotype.

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