Characterization of a dengue virus serotype 1 isolated from a patient in ciudad Juarez, Mexico

Pedro M. Palermo, Antonio de la Mora-Covarrubias, Jeanette Orbegozo, Jessica A. Plante, Kenneth S. Plante, Florinda Jimenez-Vega, Douglas M. Watts

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Dengue (DEN) is the most important human arboviral disease worldwide. Sporadic outbreaks of DEN have been reported since 1980 in urban communities located along the border in southeast Texas and northern Mexico. Other than the Rio Grande Valley region of TX, autochthonous transmission of DENV has not been reported from any other US border communities. As part of a surveillance program for arthropod-borne viruses in Ciudad Juarez, Mexico, during November 2015, a blood sample was obtained from a female patient who experienced an undifferentiated fever and arthralgia. The plasma of the sample was tested for virus in Vero-76 and C6/36 cells. DENV serotype 1 (DENV-1) was isolated in the C6/36 cells, and nucleotide sequencing of the envelope gene and full genome grouped the DENV-1 isolate in the Central America clade. The patient had not traveled outside of Ciudad Juarez, Mexico, thus suggesting DENV-1 infection was acquired in this community.

Original languageEnglish (US)
Article number872
Issue number7
StatePublished - Jul 2021


  • Central America clade
  • Dengue virus
  • Mexico

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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