Characterization of a novel coronavirus associated with severe acute respiratory syndrome

Paul A. Rota; M. Steven Oberste; Stephan S. Monroe; W. Allan Nix; Ray Campagnoli; Joseph P. Icenogle; Silvia Peñaranda; Bettina Bankamp; Kaija Maher; Min hsin Chen; Suxiong Tong; Azaibi Tamin; Luis Lowe; Michael Frace; Joseph L. DeRisi; Qi Chen; David Wang; Dean D. Erdman; Teresa C.T. Peret; Cara Burns; Thomas G. Ksiazek; Pierre E. Rollin; Anthony Sanchez; Stephanie Liffick; Brian Holloway; Josef Limor; Karen McCaustland; Mellissa Olsen-Rasmussen; Ron Fouchier; Stephan Günther; Albert D.H.E. Osterhaus; Christian Drosten; Mark A. Pallansch; Larry J. Anderson; William J. Bellini

doi:10.1126/science.1085952

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

Paul A. Rota, M. Steven Oberste, Stephan S. Monroe, W. Allan Nix, Ray Campagnoli, Joseph P. Icenogle, Silvia Peñaranda, Bettina Bankamp, Kaija Maher, Min hsin Chen, Suxiong Tong, Azaibi Tamin, Luis Lowe, Michael Frace, Joseph L. DeRisi, Qi Chen, David Wang, Dean D. Erdman, Teresa C.T. Peret, Cara BurnsThomas G. Ksiazek, Pierre E. Rollin, Anthony Sanchez, Stephanie Liffick, Brian Holloway, Josef Limor, Karen McCaustland, Mellissa Olsen-Rasmussen, Ron Fouchier, Stephan Günther, Albert D.H.E. Osterhaus, Christian Drosten, Mark A. Pallansch, Larry J. Anderson, William J. Bellini

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Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

Original language	English (US)
Pages (from-to)	1394-1399
Number of pages	6
Journal	Science
Volume	300
Issue number	5624
DOIs	https://doi.org/10.1126/science.1085952
State	Published - May 30 2003
Externally published	Yes

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Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R., Icenogle, J. P., Peñaranda, S., Bankamp, B., Maher, K., Chen, M. H., Tong, S., Tamin, A., Lowe, L., Frace, M., DeRisi, J. L., Chen, Q., Wang, D., Erdman, D. D., Peret, T. C. T., ... Bellini, W. J. (2003). Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science, 300(5624), 1394-1399. https://doi.org/10.1126/science.1085952

Rota, PA, Oberste, MS, Monroe, SS, Nix, WA, Campagnoli, R, Icenogle, JP, Peñaranda, S, Bankamp, B, Maher, K, Chen, MH, Tong, S, Tamin, A, Lowe, L, Frace, M, DeRisi, JL, Chen, Q, Wang, D, Erdman, DD, Peret, TCT, Burns, C, Ksiazek, TG, Rollin, PE, Sanchez, A, Liffick, S, Holloway, B, Limor, J, McCaustland, K, Olsen-Rasmussen, M, Fouchier, R, Günther, S, Osterhaus, ADHE, Drosten, C, Pallansch, MA, Anderson, LJ & Bellini, WJ 2003, 'Characterization of a novel coronavirus associated with severe acute respiratory syndrome', Science, vol. 300, no. 5624, pp. 1394-1399. https://doi.org/10.1126/science.1085952

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abstract = "In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.",

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AU - Peñaranda, Silvia

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AU - Tong, Suxiong

AU - Tamin, Azaibi

AU - Lowe, Luis

AU - Frace, Michael

AU - DeRisi, Joseph L.

AU - Chen, Qi

AU - Wang, David

AU - Erdman, Dean D.

AU - Peret, Teresa C.T.

AU - Burns, Cara

AU - Ksiazek, Thomas G.

AU - Rollin, Pierre E.

AU - Sanchez, Anthony

AU - Liffick, Stephanie

AU - Holloway, Brian

AU - Limor, Josef

AU - McCaustland, Karen

AU - Olsen-Rasmussen, Mellissa

AU - Fouchier, Ron

AU - Günther, Stephan

AU - Osterhaus, Albert D.H.E.

AU - Drosten, Christian

AU - Pallansch, Mark A.

AU - Anderson, Larry J.

AU - Bellini, William J.

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AB - In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

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Characterization of a novel coronavirus associated with severe acute respiratory syndrome

Abstract

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