Characterization of a novel coronavirus associated with severe acute respiratory syndrome

Paul A. Rota, M. Steven Oberste, Stephan S. Monroe, W. Allan Nix, Ray Campagnoli, Joseph P. Icenogle, Silvia Peñaranda, Bettina Bankamp, Kaija Maher, Min hsin Chen, Suxiong Tong, Azaibi Tamin, Luis Lowe, Michael Frace, Joseph L. DeRisi, Qi Chen, David Wang, Dean D. Erdman, Teresa C T Peret, Cara Burns & 15 others Thomas Ksiazek, Pierre E. Rollin, Anthony Sanchez, Stephanie Liffick, Brian Holloway, Josef Limor, Karen McCaustland, Mellissa Olsen-Rasmussen, Ron Fouchier, Stephan Günther, Albert D H E Osterhaus, Christian Drosten, Mark A. Pallansch, Larry J. Anderson, William J. Bellini

Research output: Contribution to journalArticle

1567 Citations (Scopus)

Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

Original languageEnglish (US)
Pages (from-to)1394-1399
Number of pages6
JournalScience
Volume300
Issue number5624
DOIs
StatePublished - May 30 2003
Externally publishedYes

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Severe Acute Respiratory Syndrome
Coronavirus
Genome
Viral Genome
Open Reading Frames
Sequence Analysis
Nucleotides

ASJC Scopus subject areas

  • General

Cite this

Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R., Icenogle, J. P., ... Bellini, W. J. (2003). Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science, 300(5624), 1394-1399. https://doi.org/10.1126/science.1085952

Characterization of a novel coronavirus associated with severe acute respiratory syndrome. / Rota, Paul A.; Oberste, M. Steven; Monroe, Stephan S.; Nix, W. Allan; Campagnoli, Ray; Icenogle, Joseph P.; Peñaranda, Silvia; Bankamp, Bettina; Maher, Kaija; Chen, Min hsin; Tong, Suxiong; Tamin, Azaibi; Lowe, Luis; Frace, Michael; DeRisi, Joseph L.; Chen, Qi; Wang, David; Erdman, Dean D.; Peret, Teresa C T; Burns, Cara; Ksiazek, Thomas; Rollin, Pierre E.; Sanchez, Anthony; Liffick, Stephanie; Holloway, Brian; Limor, Josef; McCaustland, Karen; Olsen-Rasmussen, Mellissa; Fouchier, Ron; Günther, Stephan; Osterhaus, Albert D H E; Drosten, Christian; Pallansch, Mark A.; Anderson, Larry J.; Bellini, William J.

In: Science, Vol. 300, No. 5624, 30.05.2003, p. 1394-1399.

Research output: Contribution to journalArticle

Rota, PA, Oberste, MS, Monroe, SS, Nix, WA, Campagnoli, R, Icenogle, JP, Peñaranda, S, Bankamp, B, Maher, K, Chen, MH, Tong, S, Tamin, A, Lowe, L, Frace, M, DeRisi, JL, Chen, Q, Wang, D, Erdman, DD, Peret, TCT, Burns, C, Ksiazek, T, Rollin, PE, Sanchez, A, Liffick, S, Holloway, B, Limor, J, McCaustland, K, Olsen-Rasmussen, M, Fouchier, R, Günther, S, Osterhaus, ADHE, Drosten, C, Pallansch, MA, Anderson, LJ & Bellini, WJ 2003, 'Characterization of a novel coronavirus associated with severe acute respiratory syndrome', Science, vol. 300, no. 5624, pp. 1394-1399. https://doi.org/10.1126/science.1085952
Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science. 2003 May 30;300(5624):1394-1399. https://doi.org/10.1126/science.1085952
Rota, Paul A. ; Oberste, M. Steven ; Monroe, Stephan S. ; Nix, W. Allan ; Campagnoli, Ray ; Icenogle, Joseph P. ; Peñaranda, Silvia ; Bankamp, Bettina ; Maher, Kaija ; Chen, Min hsin ; Tong, Suxiong ; Tamin, Azaibi ; Lowe, Luis ; Frace, Michael ; DeRisi, Joseph L. ; Chen, Qi ; Wang, David ; Erdman, Dean D. ; Peret, Teresa C T ; Burns, Cara ; Ksiazek, Thomas ; Rollin, Pierre E. ; Sanchez, Anthony ; Liffick, Stephanie ; Holloway, Brian ; Limor, Josef ; McCaustland, Karen ; Olsen-Rasmussen, Mellissa ; Fouchier, Ron ; Günther, Stephan ; Osterhaus, Albert D H E ; Drosten, Christian ; Pallansch, Mark A. ; Anderson, Larry J. ; Bellini, William J. / Characterization of a novel coronavirus associated with severe acute respiratory syndrome. In: Science. 2003 ; Vol. 300, No. 5624. pp. 1394-1399.
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