Characterization of an acid-inducible sulfatase in Salmonella enterica serovar typhimurium

Seema Das; Swati Singh; Michael McClelland; Steven Forest; Prasad Gyaneshwar

doi:10.1128/AEM.03707-12

Characterization of an acid-inducible sulfatase in Salmonella enterica serovar typhimurium

Seema Das
, Swati Singh
, Michael McClelland
, Steven Forest
, Prasad Gyaneshwar

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis.

Original language	English (US)
Pages (from-to)	2092-2095
Number of pages	4
Journal	Applied and Environmental Microbiology
Volume	79
Issue number	6
DOIs	https://doi.org/10.1128/AEM.03707-12
State	Published - Mar 2013
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology
Ecology

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abstract = "Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis.",

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AU - Das, Seema

AU - Singh, Swati

AU - McClelland, Michael

AU - Forest, Steven

AU - Gyaneshwar, Prasad

PY - 2013/3

Y1 - 2013/3

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AB - Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis.

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UR - https://www.scopus.com/pages/publications/84874792136#tab=citedBy

U2 - 10.1128/AEM.03707-12

DO - 10.1128/AEM.03707-12

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AN - SCOPUS:84874792136

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JO - Applied and Environmental Microbiology

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IS - 6

ER -

Characterization of an acid-inducible sulfatase in Salmonella enterica serovar typhimurium

Abstract

ASJC Scopus subject areas

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