Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

Adin Shniffer, Danielle D. Visschedyk, Ravikiran Ravulapalli, Giovanni Suarez, Zachari J. Turgeon, Anthony A. Petrie, Ashok K. Chopra, A. Rod Merrill

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD+. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.

Original languageEnglish (US)
Pages (from-to)37030-37041
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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