Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

Adin Shniffer; Danielle D. Visschedyk; Ravikiran Ravulapalli; Giovanni Suarez; Zachari J. Turgeon; Anthony A. Petrie; Ashok K. Chopra; A. Rod Merrill

doi:10.1074/jbc.M112.397612

Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

Adin Shniffer, Danielle D. Visschedyk, Ravikiran Ravulapalli, Giovanni Suarez, Zachari J. Turgeon, Anthony A. Petrie, Ashok K. Chopra, A. Rod Merrill

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD⁺. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.

Original language	English (US)
Pages (from-to)	37030-37041
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.397612
State	Published - Oct 26 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila",

abstract = "Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD+. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.",

author = "Adin Shniffer and Visschedyk, {Danielle D.} and Ravikiran Ravulapalli and Giovanni Suarez and Turgeon, {Zachari J.} and Petrie, {Anthony A.} and Chopra, {Ashok K.} and Merrill, {A. Rod}",

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doi = "10.1074/jbc.M112.397612",

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T1 - Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

AU - Shniffer, Adin

AU - Visschedyk, Danielle D.

AU - Ravulapalli, Ravikiran

AU - Suarez, Giovanni

AU - Turgeon, Zachari J.

AU - Petrie, Anthony A.

AU - Chopra, Ashok K.

AU - Merrill, A. Rod

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD+. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.

AB - Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD+. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.

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ER -

Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

Abstract

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