Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

Adin Shniffer; Danielle D. Visschedyk; Ravikiran Ravulapalli; Giovanni Suarez; Zachari J. Turgeon; Anthony A. Petrie; Ashok K. Chopra; A. Rod Merrill

doi:10.1074/jbc.M112.397612

Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

Adin Shniffer
, Danielle D. Visschedyk
, Ravikiran Ravulapalli
, Giovanni Suarez
, Zachari J. Turgeon
, Anthony A. Petrie
, Ashok K. Chopra
, A. Rod Merrill

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD⁺. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.

Original language	English (US)
Pages (from-to)	37030-37041
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.397612
State	Published - Oct 26 2012

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.397612

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title = "Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila",

abstract = "Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD+. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.",

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doi = "10.1074/jbc.M112.397612",

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AU - Shniffer, Adin

AU - Visschedyk, Danielle D.

AU - Ravulapalli, Ravikiran

AU - Suarez, Giovanni

AU - Turgeon, Zachari J.

AU - Petrie, Anthony A.

AU - Chopra, Ashok K.

AU - Merrill, A. Rod

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD+. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.

AB - Background: VahC toxin from Aeromonas hydrophila inactivates actin by transferring ADP-ribose from NAD+. Results: The crystal structure of VahC reveals new insights into the interaction of the actin substrate with the actin-targeting toxins, and consequently, potent inhibitors have been developed. Conclusion: Broad spectrum inhibitors have been developed against actin-targeting toxins from the ADP-ribosyltransferase family. Significance: This new insight provides impetus for therapeutic development for treating bacterial diseases.

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SP - 37030

EP - 37041

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 44

ER -

Characterization of an actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila

Abstract

ASJC Scopus subject areas

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