Characterization of cells infiltrating the lungs of X-irradiated and nude mice after influenza virus infection

E. Shimomura, Fujio Suzuki, N. Ishida

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

After X-irradiated and nonirradiated mice (C3H/He), as well as athymic nude mice and haired littermates (BALB/c), were infected with influenza A virus (Kumamoto strain, H2N2), they were examined for survival period, the development of consolidation in the lungs and the characteristics of the cells infiltrating the lung tissues. In two different T-cell deficient groups, there was a definite delay in the development of consolidation compared with their respective controls and this was reflected in prolonged survival perods: 5 days longer for irradiated mice and 6 days longer for nude mice. In both T-cell deficient and normal groups, about 70% of the cells obtained from consolidated lung tissues after virus infection were found to be small lymhoid cells and there were no morphological differences between the T-cell deficient and normal groups. None of these small lymphoid cells from the peripheral bldood or the spleens of T-cell deficient mice responded to concanavalin A. In the lungs of both X-irradiated mice and nude mice, however, a definite increase in cells having natural killer activity was found at the later stages of the influenza infection, suggesting their participation in the development of consolidation.

Original languageEnglish (US)
Pages (from-to)129-138
Number of pages10
JournalMicrobiology and Immunology
Volume26
Issue number2
StatePublished - 1982
Externally publishedYes

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Virus Diseases
Orthomyxoviridae
Nude Mice
T-Lymphocytes
Lung
Inbred C3H Mouse
Influenza A virus
Concanavalin A
Natural Killer Cells
Human Influenza
Spleen
Lymphocytes
Infection

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology
  • Microbiology (medical)

Cite this

Characterization of cells infiltrating the lungs of X-irradiated and nude mice after influenza virus infection. / Shimomura, E.; Suzuki, Fujio; Ishida, N.

In: Microbiology and Immunology, Vol. 26, No. 2, 1982, p. 129-138.

Research output: Contribution to journalArticle

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