Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae

Gustavo Palacios; Naomi L. Forrester; Nazir Savji; Amelia P.A. Travassos Da Rosa; Hilda Guzman; Kelly Detoy; Vsevolod L. Popov; Peter J. Walker; W. Ian Lipkin; Nikos Vasilakis; Robert B. Tesh

doi:10.1186/1743-422X-10-219

Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae

Gustavo Palacios, Naomi L. Forrester, Nazir Savji, Amelia P.A. Travassos Da Rosa, Hilda Guzman, Kelly Detoy, Vsevolod L. Popov, Peter J. Walker, W. Ian Lipkin, Nikos Vasilakis, Robert B. Tesh

Pathology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. Findings. Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae. Conclusions: In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae.

Original language	English (US)
Article number	219
Journal	Virology journal
Volume	10
DOIs	https://doi.org/10.1186/1743-422X-10-219
State	Published - 2013

Keywords

Family Rhabdoviridae
Farmington virus (FARV)
Next generation sequencing
Phylogeny

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1186/1743-422X-10-219

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Palacios, G., Forrester, N. L., Savji, N., Travassos Da Rosa, A. P. A., Guzman, H., Detoy, K., Popov, V. L., Walker, P. J., Lipkin, W. I., Vasilakis, N., & Tesh, R. B. (2013). Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae. Virology journal, 10, Article 219. https://doi.org/10.1186/1743-422X-10-219

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title = "Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae",

abstract = "Background: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. Findings. Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae. Conclusions: In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae.",

keywords = "Family Rhabdoviridae, Farmington virus (FARV), Next generation sequencing, Phylogeny",

author = "Gustavo Palacios and Forrester, {Naomi L.} and Nazir Savji and {Travassos Da Rosa}, {Amelia P.A.} and Hilda Guzman and Kelly Detoy and Popov, {Vsevolod L.} and Walker, {Peter J.} and Lipkin, {W. Ian} and Nikos Vasilakis and Tesh, {Robert B.}",

note = "Funding Information: We thank Farooq Nasar for his critical review of this manuscript. This work is supported in part by the Department of Pathology start up funds, a grant from the Institute for Human Infections and Immunity, University of Texas Medical Branch (NV), NIH contract HHSN272201000040I/HHSN27200004/D04 (RBT), the Institute for Human Infections and Immunity Pathogen Genomics Program (NLF), AI157158 (Northeast Biodefense Center-Lipkin) and the Defense Threat Reduction Agency.",

year = "2013",

doi = "10.1186/1743-422X-10-219",

language = "English (US)",

volume = "10",

journal = "Virology journal",

issn = "1743-422X",

publisher = "BioMed Central Ltd.",

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T1 - Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae

AU - Palacios, Gustavo

AU - Forrester, Naomi L.

AU - Savji, Nazir

AU - Travassos Da Rosa, Amelia P.A.

AU - Guzman, Hilda

AU - Detoy, Kelly

AU - Popov, Vsevolod L.

AU - Walker, Peter J.

AU - Lipkin, W. Ian

AU - Vasilakis, Nikos

AU - Tesh, Robert B.

N1 - Funding Information: We thank Farooq Nasar for his critical review of this manuscript. This work is supported in part by the Department of Pathology start up funds, a grant from the Institute for Human Infections and Immunity, University of Texas Medical Branch (NV), NIH contract HHSN272201000040I/HHSN27200004/D04 (RBT), the Institute for Human Infections and Immunity Pathogen Genomics Program (NLF), AI157158 (Northeast Biodefense Center-Lipkin) and the Defense Threat Reduction Agency.

PY - 2013

Y1 - 2013

N2 - Background: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. Findings. Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae. Conclusions: In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae.

AB - Background: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. Findings. Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae. Conclusions: In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae.

KW - Family Rhabdoviridae

KW - Farmington virus (FARV)

KW - Next generation sequencing

KW - Phylogeny

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Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae

Abstract

Keywords

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