Characterization of Fort Morgan virus, an alphavirus of the western equine encephalitis virus complex in an unusual ecosystem

C. H. Calisher, T. P. Monath, D. J. Muth, J. S. Lazuick, D. W. Trent, D. B. Francy, G. E. Kemp, F. W. Chandler

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

An alphavirus isolated from nestling Cliff Swallows (Petrochelidon pyrrhonota) and House Sparrows (Passer domesticus) and from cimicid bugs (Oeciacus vicarius) in eastern Colorado, for which we propose the name Fort Morgan (FM) virus, is sensitive to the action of sodium deoxycholate, unstable at pH 2.0-4.0, and demonstrates no characteristics of temperature-sensitive mutants. Unpassaged field strains are nonpathogenic, or of low pathogenicity, for suckling mice; however, plaque-purified FM virus is pathogenic for a variety of laboratory hosts. By hemagglutination-inhibition (HI), complement-fixation, and neutralization tests, cross-reactions were observed between FM virus and members of the western equine encephalitis (WEE) virus antigenic complex. Short-incubation HI tests indicated that the new isolate shared closer antigenic relationships with WEE complex virus strains from the eastern United States (Highlands J virus) than with other WEE complex viruses. On the basis of these serological findings, as well as characterization of the structural polypeptides and oligonucleotides, we suggest that FM is a distinct virus belonging to the WEE antigenic complex. A reconsideration of the taxonomy of the WEE complex and discussion of the epizoologic significance of FM virus are presented.

Original languageEnglish (US)
Pages (from-to)1428-1440
Number of pages13
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume29
Issue number6
StatePublished - 1980

Fingerprint

Western Equine Encephalitis Viruses
Alphavirus
Ecosystem
Viruses
Western Equine Encephalomyelitis
Sparrows
Swallows
Hemagglutination Inhibition Tests
Complement Fixation Tests
Neutralization Tests
Deoxycholic Acid
Cross Reactions
Hemagglutination
Oligonucleotides
Names
Virulence
Peptides
Temperature

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Calisher, C. H., Monath, T. P., Muth, D. J., Lazuick, J. S., Trent, D. W., Francy, D. B., ... Chandler, F. W. (1980). Characterization of Fort Morgan virus, an alphavirus of the western equine encephalitis virus complex in an unusual ecosystem. American Journal of Tropical Medicine and Hygiene, 29(6), 1428-1440.

Characterization of Fort Morgan virus, an alphavirus of the western equine encephalitis virus complex in an unusual ecosystem. / Calisher, C. H.; Monath, T. P.; Muth, D. J.; Lazuick, J. S.; Trent, D. W.; Francy, D. B.; Kemp, G. E.; Chandler, F. W.

In: American Journal of Tropical Medicine and Hygiene, Vol. 29, No. 6, 1980, p. 1428-1440.

Research output: Contribution to journalArticle

Calisher, CH, Monath, TP, Muth, DJ, Lazuick, JS, Trent, DW, Francy, DB, Kemp, GE & Chandler, FW 1980, 'Characterization of Fort Morgan virus, an alphavirus of the western equine encephalitis virus complex in an unusual ecosystem', American Journal of Tropical Medicine and Hygiene, vol. 29, no. 6, pp. 1428-1440.
Calisher, C. H. ; Monath, T. P. ; Muth, D. J. ; Lazuick, J. S. ; Trent, D. W. ; Francy, D. B. ; Kemp, G. E. ; Chandler, F. W. / Characterization of Fort Morgan virus, an alphavirus of the western equine encephalitis virus complex in an unusual ecosystem. In: American Journal of Tropical Medicine and Hygiene. 1980 ; Vol. 29, No. 6. pp. 1428-1440.
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