Characterization of host immune responses in Ebola virus infections

Gary Wong, Gary P. Kobinger, Xiangguo Qiu

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations

Abstract

Ebola causes highly lethal hemorrhagic fever in humans with no licensed countermeasures. Its virulence can be attributed to several immunoevasion mechanisms: an early inhibition of innate immunity started by the downregulation of type I interferon, epitope masking and subversion of the adaptive humoural immunity by secreting a truncated form of the viral glycoprotein. Deficiencies in specific and non-specific antiviral responses result in unrestricted viral replication and dissemination in the host, causing death typically within 10 days after the appearance of symptoms. This review summarizes the host immune response to Ebola infection, and highlights the short-and long-term immune responses crucial for protection, which holds implications for the design of future vaccines and therapeutics.

Original languageEnglish (US)
Pages (from-to)781-790
Number of pages10
JournalExpert Review of Clinical Immunology
Volume10
Issue number6
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • adaptive immunity
  • antigenic subversion
  • Ebola
  • immunoevasion
  • innate immunity
  • long-term immunity
  • secreted glycoprotein
  • type I IFN

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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