Characterization of Mount Elgon Bat virus, a new member of the Rhabdovirus group

Frederick A. Murphy, Robert E. Shope, D. Metselaar, D. I H Simpson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mount Elgon Bat (MEB) virus, an isolate from a Rhinolophus hildebrandtii eloquens (K. Anderson) bat from Kenya, was examined by negative contrast and thin-section electron microscopy. It was found in infected mouse brain tissue to be bullet-shaped with structural details similar to other viruses of the Rhabdovirus group. Virus particles had a mean length of 226 nm and were 68 nm in diameter. The internal helically wound cylinder consisted of a single strand approximately 10 nm in diameter. In mouse brain, virus maturation occurred upon plasma membranes; viral matrix or inclusion material was in many cases located in the cytoplasm beneath sites of viral budding. The matrix consisted of convoluted filaments or strands. Complement-fixation, neutralization, and immunodiffusion tests comparing MEB virus with all the known Rhabdoviruses of animals failed to show any cross-reactivity. The described characteristics form the basis for considering MEB as an antigenically distinct member of the Rhabdovirus group.

Original languageEnglish (US)
Pages (from-to)288-297
Number of pages10
JournalVirology
Volume40
Issue number2
DOIs
StatePublished - 1970

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Rhabdoviridae
Viruses
Neutralization Tests
Immunodiffusion
Kenya
Brain
Virion
Electron Microscopy
Cytoplasm
Cell Membrane
Wounds and Injuries

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Murphy, F. A., Shope, R. E., Metselaar, D., & Simpson, D. I. H. (1970). Characterization of Mount Elgon Bat virus, a new member of the Rhabdovirus group. Virology, 40(2), 288-297. https://doi.org/10.1016/0042-6822(70)90404-6

Characterization of Mount Elgon Bat virus, a new member of the Rhabdovirus group. / Murphy, Frederick A.; Shope, Robert E.; Metselaar, D.; Simpson, D. I H.

In: Virology, Vol. 40, No. 2, 1970, p. 288-297.

Research output: Contribution to journalArticle

Murphy, FA, Shope, RE, Metselaar, D & Simpson, DIH 1970, 'Characterization of Mount Elgon Bat virus, a new member of the Rhabdovirus group', Virology, vol. 40, no. 2, pp. 288-297. https://doi.org/10.1016/0042-6822(70)90404-6
Murphy, Frederick A. ; Shope, Robert E. ; Metselaar, D. ; Simpson, D. I H. / Characterization of Mount Elgon Bat virus, a new member of the Rhabdovirus group. In: Virology. 1970 ; Vol. 40, No. 2. pp. 288-297.
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