TY - JOUR
T1 - Characterization of Mount Elgon Bat virus, a new member of the Rhabdovirus group
AU - Murphy, Frederick A.
AU - Shope, Robert E.
AU - Metselaar, D.
AU - Simpson, D. I.H.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1970/2
Y1 - 1970/2
N2 - Mount Elgon Bat (MEB) virus, an isolate from a Rhinolophus hildebrandtii eloquens (K. Anderson) bat from Kenya, was examined by negative contrast and thin-section electron microscopy. It was found in infected mouse brain tissue to be bullet-shaped with structural details similar to other viruses of the Rhabdovirus group. Virus particles had a mean length of 226 nm and were 68 nm in diameter. The internal helically wound cylinder consisted of a single strand approximately 10 nm in diameter. In mouse brain, virus maturation occurred upon plasma membranes; viral matrix or inclusion material was in many cases located in the cytoplasm beneath sites of viral budding. The matrix consisted of convoluted filaments or strands. Complement-fixation, neutralization, and immunodiffusion tests comparing MEB virus with all the known Rhabdoviruses of animals failed to show any cross-reactivity. The described characteristics form the basis for considering MEB as an antigenically distinct member of the Rhabdovirus group.
AB - Mount Elgon Bat (MEB) virus, an isolate from a Rhinolophus hildebrandtii eloquens (K. Anderson) bat from Kenya, was examined by negative contrast and thin-section electron microscopy. It was found in infected mouse brain tissue to be bullet-shaped with structural details similar to other viruses of the Rhabdovirus group. Virus particles had a mean length of 226 nm and were 68 nm in diameter. The internal helically wound cylinder consisted of a single strand approximately 10 nm in diameter. In mouse brain, virus maturation occurred upon plasma membranes; viral matrix or inclusion material was in many cases located in the cytoplasm beneath sites of viral budding. The matrix consisted of convoluted filaments or strands. Complement-fixation, neutralization, and immunodiffusion tests comparing MEB virus with all the known Rhabdoviruses of animals failed to show any cross-reactivity. The described characteristics form the basis for considering MEB as an antigenically distinct member of the Rhabdovirus group.
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U2 - 10.1016/0042-6822(70)90404-6
DO - 10.1016/0042-6822(70)90404-6
M3 - Article
C2 - 4985858
AN - SCOPUS:0014736662
SN - 0042-6822
VL - 40
SP - 288
EP - 297
JO - Virology
JF - Virology
IS - 2
ER -