Characterization of outer membrane porins expressed by E. coli O157: H7: Observed lowered permeability characteristics and correlation to potential drug targets

Michael B. Martinez, Silvia M. Pulido, Thomas Krick, LeeAnn Higgins, Bruce Witthuhn, Michael Flickinger, Mark Emmett, Alan G. Marshall, Gary L. Nelsestuen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The characterization of outer membrane porins expressed by Escherichia coli (E.coli) O157:H7 is discussed. It is found that E.coli, an intestinal bacterium present in beef, is responsible for outbreaks of infection in many parts of the world. Initial infection by E.coli strain O157:H7 occurs when bacteria enter the body through the stomach. A possible contributor to the molecular basis of superior survival may be an altered outer membrane, which creates resistance to acidic stomach pH, bile salts, dilute environments such as well water and other antimicrobial conditions.

Original languageEnglish (US)
Title of host publicationProceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Pages345-346
Number of pages2
StatePublished - 2002
Externally publishedYes
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

Fingerprint

Porins
Escherichia coli
Membranes
Bacteria
Pharmaceutical Preparations
Beef
Bile Acids and Salts
Water

ASJC Scopus subject areas

  • Spectroscopy

Cite this

Martinez, M. B., Pulido, S. M., Krick, T., Higgins, L., Witthuhn, B., Flickinger, M., ... Nelsestuen, G. L. (2002). Characterization of outer membrane porins expressed by E. coli O157: H7: Observed lowered permeability characteristics and correlation to potential drug targets. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 345-346)

Characterization of outer membrane porins expressed by E. coli O157 : H7: Observed lowered permeability characteristics and correlation to potential drug targets. / Martinez, Michael B.; Pulido, Silvia M.; Krick, Thomas; Higgins, LeeAnn; Witthuhn, Bruce; Flickinger, Michael; Emmett, Mark; Marshall, Alan G.; Nelsestuen, Gary L.

Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics. 2002. p. 345-346.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Martinez, MB, Pulido, SM, Krick, T, Higgins, L, Witthuhn, B, Flickinger, M, Emmett, M, Marshall, AG & Nelsestuen, GL 2002, Characterization of outer membrane porins expressed by E. coli O157: H7: Observed lowered permeability characteristics and correlation to potential drug targets. in Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics. pp. 345-346, Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 6/2/02.
Martinez MB, Pulido SM, Krick T, Higgins L, Witthuhn B, Flickinger M et al. Characterization of outer membrane porins expressed by E. coli O157: H7: Observed lowered permeability characteristics and correlation to potential drug targets. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics. 2002. p. 345-346
Martinez, Michael B. ; Pulido, Silvia M. ; Krick, Thomas ; Higgins, LeeAnn ; Witthuhn, Bruce ; Flickinger, Michael ; Emmett, Mark ; Marshall, Alan G. ; Nelsestuen, Gary L. / Characterization of outer membrane porins expressed by E. coli O157 : H7: Observed lowered permeability characteristics and correlation to potential drug targets. Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics. 2002. pp. 345-346
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