Characterization of Sudan Ebolavirus infection in ferrets

Andrea Kroeker; Shihua He; Marc Antoine de La Vega; Gary Wong; Carissa Embury-Hyatt; Xiangguo Qiu

doi:10.18632/oncotarget.17694

Characterization of Sudan Ebolavirus infection in ferrets

Andrea Kroeker, Shihua He, Marc Antoine de La Vega, Gary Wong, Carissa Embury-Hyatt, Xiangguo Qiu

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental compounds and should only be used to test the most promising candidates. Therefore, other smaller animal models are a valuable asset. We have recently developed a guinea-pig adapted SUDV virus that is lethal in guinea pigs. In our current study, we show that ferrets are susceptible to wild-type SUDV, providing a small animal model to directly study clinical isolates, screen experimental anti-SUDV compounds and potentially study viral transmission.

Original language	English (US)
Pages (from-to)	46262-46272
Number of pages	11
Journal	Oncotarget
Volume	8
Issue number	28
DOIs	https://doi.org/10.18632/oncotarget.17694
State	Published - 2017
Externally published	Yes

Keywords

Animal model
Characterization
Ebolavirus
Ferrets
Sudan

ASJC Scopus subject areas

Oncology

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10.18632/oncotarget.17694

Cite this

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title = "Characterization of Sudan Ebolavirus infection in ferrets",

abstract = "Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental compounds and should only be used to test the most promising candidates. Therefore, other smaller animal models are a valuable asset. We have recently developed a guinea-pig adapted SUDV virus that is lethal in guinea pigs. In our current study, we show that ferrets are susceptible to wild-type SUDV, providing a small animal model to directly study clinical isolates, screen experimental anti-SUDV compounds and potentially study viral transmission.",

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AU - He, Shihua

AU - Vega, Marc Antoine de La

AU - Wong, Gary

AU - Embury-Hyatt, Carissa

AU - Qiu, Xiangguo

N1 - Publisher Copyright: © Kroeker et al.

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Characterization of Sudan Ebolavirus infection in ferrets

Abstract

Keywords

ASJC Scopus subject areas

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