Characterization of the changuinola serogroup viruses (Reoviridae: Orbivirus)

A. P.A. Travassos Da Rosa, R. B. Tesh, F. P. Pinheiro, J. F.S. Travassos Da Rosa, P. H. Peralta, D. L. Knudson

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The antigenic, biological, and chemical properties of 24 selected Changuinola serogroup viruses were examined. The viruses tested were chloroform-resistant, and they were lethal to newborn hamsters after intracerebral inoculation. The prototype Changuinola virus strain (BT-436) replicated in mosquito and sandfly cell cultures. In complement-fixation tests, the viruses were broadly cross-reacting and indistinguishable but by neutralization test at least 12 distinct serotypes were identified, and by PAGE of double-stranded RNA 22 distinct profiles were found. These data suggest that the Changuinola serogroup may be comprised of a large number of genetically different viruses. A brief review of the natural history of Changuinola serogroup viruses is also given.

Original languageEnglish (US)
Pages (from-to)38-49
Number of pages12
JournalIntervirology
Volume21
Issue number1
DOIs
StatePublished - 1984

Keywords

  • Changuinola serogroup
  • Double-stranded RNA
  • Orbivirus
  • Serology
  • Taxonomy

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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