Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family)

Jannifer Oliveira Chiang, William Marciel de Souza, Márcio Roberto Teixeira Nunes, Gustavo Olszanski Acrani, Amélia Paes de Andrade Travassos da Rosa, Nelma Mesquita de Freitas, Sandro Patroca da Silva, Pedro Henrique Dorta da Silva, Alana Watanabe de Sousa, Sueli Guerreiro Rodrigues, Juarez Antônio Simões Quaresma, Bedsy Dutary, Hilda Guzmán, Nikos Vasilakis, Robert B. Tesh, Pedro Fernando da Costa Vasconcelos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Comprehensive comparative phylogenetic analyses were performed on 17 Gamboa serogroup viruses (GAMSVs) from distinct geographic regions in the Americas and other representative members of the genus Orthobunyavirus (Peribunyaviridae), based on small (S), medium (M), and large (L) open reading frame full-length and partial sequences. Genome characterization showed that the GAMSVs divide into four clades or genotypes. The GAMSVs have a genetic organization similar to other orthobunyaviruses, except that they have a larger NSm protein than other orthobunyaviruses. A serosurvey for Gamboa virus antibodies was performed in plasma from birds, other wild animals, and humans living around the Tucuruí hydroelectric dam in Pará state, northern Brazil, a known focus of GAMSV activity. Newborn chicks (Gallus gallus domesticus) were experimentally infected with a GAMSV, and the pathogenesis is described. Histopathological changes were primarily in the lungs and liver. Also, a review of the ecology of the GAMSVs in the Americas is included. In sum, this study presents the genomic and evolutionary characterization of the Gamboa group and the potential model of pathogenesis, which would be helpful for diagnostic purposes, epidemiology, and immuno-pathogenesis studies.

Original languageEnglish (US)
Pages (from-to)1502-1511
Number of pages10
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number5
DOIs
StatePublished - Jan 1 2018

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Orthobunyavirus
Viruses
Wild Animals
Serogroup
Ecology
Open Reading Frames
Birds
Brazil
Chickens
Epidemiology
Genotype
Genome
Lung
Antibodies
Liver

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Chiang, J. O., de Souza, W. M., Nunes, M. R. T., Acrani, G. O., Travassos da Rosa, A. P. D. A., de Freitas, N. M., ... Vasconcelos, P. F. D. C. (2018). Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family). American Journal of Tropical Medicine and Hygiene, 98(5), 1502-1511. https://doi.org/10.4269/ajtmh.17-0810

Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family). / Chiang, Jannifer Oliveira; de Souza, William Marciel; Nunes, Márcio Roberto Teixeira; Acrani, Gustavo Olszanski; Travassos da Rosa, Amélia Paes de Andrade; de Freitas, Nelma Mesquita; da Silva, Sandro Patroca; da Silva, Pedro Henrique Dorta; de Sousa, Alana Watanabe; Rodrigues, Sueli Guerreiro; Quaresma, Juarez Antônio Simões; Dutary, Bedsy; Guzmán, Hilda; Vasilakis, Nikos; Tesh, Robert B.; Vasconcelos, Pedro Fernando da Costa.

In: American Journal of Tropical Medicine and Hygiene, Vol. 98, No. 5, 01.01.2018, p. 1502-1511.

Research output: Contribution to journalArticle

Chiang, JO, de Souza, WM, Nunes, MRT, Acrani, GO, Travassos da Rosa, APDA, de Freitas, NM, da Silva, SP, da Silva, PHD, de Sousa, AW, Rodrigues, SG, Quaresma, JAS, Dutary, B, Guzmán, H, Vasilakis, N, Tesh, RB & Vasconcelos, PFDC 2018, 'Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family)', American Journal of Tropical Medicine and Hygiene, vol. 98, no. 5, pp. 1502-1511. https://doi.org/10.4269/ajtmh.17-0810
Chiang JO, de Souza WM, Nunes MRT, Acrani GO, Travassos da Rosa APDA, de Freitas NM et al. Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family). American Journal of Tropical Medicine and Hygiene. 2018 Jan 1;98(5):1502-1511. https://doi.org/10.4269/ajtmh.17-0810
Chiang, Jannifer Oliveira ; de Souza, William Marciel ; Nunes, Márcio Roberto Teixeira ; Acrani, Gustavo Olszanski ; Travassos da Rosa, Amélia Paes de Andrade ; de Freitas, Nelma Mesquita ; da Silva, Sandro Patroca ; da Silva, Pedro Henrique Dorta ; de Sousa, Alana Watanabe ; Rodrigues, Sueli Guerreiro ; Quaresma, Juarez Antônio Simões ; Dutary, Bedsy ; Guzmán, Hilda ; Vasilakis, Nikos ; Tesh, Robert B. ; Vasconcelos, Pedro Fernando da Costa. / Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family). In: American Journal of Tropical Medicine and Hygiene. 2018 ; Vol. 98, No. 5. pp. 1502-1511.
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AU - Acrani, Gustavo Olszanski

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