TY - JOUR
T1 - Characterization of three new insect-specific flaviviruses
T2 - Their relationship to the mosquito-borne flavivirus pathogens
AU - Guzman, Hilda
AU - Contreras-Gutierrez, Maria Angelica
AU - Travassos da Rosa, Amelia P.A.
AU - Nunes, Marcio R.T.
AU - Cardoso, Jedson F.
AU - Popov, Vsevolod L.
AU - Young, Katherine I.
AU - Savit, Chelsea
AU - Wood, Thomas G.
AU - Widen, Steven G.
AU - Watts, Douglas M.
AU - Hanley, Kathryn A.
AU - Perera, David
AU - Fish, Durland
AU - Vasilakis, Nikos
AU - Tesh, Robert B.
N1 - Funding Information:
Acknowledgments: We acknowledge support from the Yale Institute for Biospheric Studies Center for EcoEpidemiology and from the U.S. National Park Service (Collecting Permit #EVER-2013-SCI-0032). We are indebted to Dr. Maria R. Mendez Lopez and Carolina Guevara for providing La Tina virus and William Maciel de Souza for help in developing the phylogenetic tree.
Funding Information:
Financial support: This work was funded in part by grant R24AI120942 and by contract HHSN272201000040I/HHSN27200004/D04 from the National Institutes of Health and a pilot grant by the Institute of Human Infections and Immunity. MAC was supported by a Pro-grama de Doctorados Nacionales-Colciencias (Convocatoria 567) Ph.D. fellowship.
Publisher Copyright:
Copyright © 2018 by The American Society of Tropical Medicine and Hygiene.
PY - 2018
Y1 - 2018
N2 - Three novel insect-specific flaviviruses, isolated from mosquitoes collected in Peru, Malaysia (Sarawak), and the United States, are characterized. The new viruses, designated La Tina, Kampung Karu, and Long Pine Key, respectively, are antigenically and phylogenetically more similar to the mosquito-borne flavivirus pathogens, than to the classical insect-specific viruses like cell fusing agent and Culex flavivirus. The potential implications of this relationship and the possible uses of these and other arbovirus-related insect-specific flaviviruses are reviewed.
AB - Three novel insect-specific flaviviruses, isolated from mosquitoes collected in Peru, Malaysia (Sarawak), and the United States, are characterized. The new viruses, designated La Tina, Kampung Karu, and Long Pine Key, respectively, are antigenically and phylogenetically more similar to the mosquito-borne flavivirus pathogens, than to the classical insect-specific viruses like cell fusing agent and Culex flavivirus. The potential implications of this relationship and the possible uses of these and other arbovirus-related insect-specific flaviviruses are reviewed.
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U2 - 10.4269/ajtmh.17-0350
DO - 10.4269/ajtmh.17-0350
M3 - Article
C2 - 29016330
AN - SCOPUS:85041499285
SN - 0002-9637
VL - 98
SP - 410
EP - 419
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 2
ER -