Characterization of triniti virus supports its reclassification in the family peribunyaviridae

Juliana Abreu Lima, Joaquim Pinto Nunes Neto, Karoline Silva Castro, Amélia Paes de Andrade Travassos da Rosa, Robert Tesh, Márcio Roberto Teixeira Nunes, Vsevolod Leonidovich Popov, Nikos Vasilakis, Hilda Guzman, Steven Widen, Sandro Patroca da Silva, Daniele Barbosa de Almeida Medeiros, Jedson Ferreira Cardoso, Lívia Carício Martins, Raimunda do Socorro da Silva Azevedo, Pedro Fernando da Costa Vasconcelos, Jannifer Oliveira Chiang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Triniti virus (TNTV) has been isolated in Trinidad and Tobago and in Brazil. To date little is known about this virus, which is classified as an ungrouped virus within the family Togaviridae. Here, three isolates of TNTV were characterized both genetically and antigenically. The genome was shown to contain three RNA segments: small (S), medium (M) and large (L). Genome organization, protein sizes and protein motifs were similar to those of viruses in the genus Orthobunyavirus, family Peribunyaviridae. Antigenic reactivity revealed the three TNTV isolates to be closely related, but no serologic cross-reaction with other orthobunyaviruses. Morphological observation by transmission electron microscopy indicated that virus size and symmetry were compatible with those of viruses in the family Peribunyaviridae. Our serological, morphological and molecular results support the taxonomic reclassification of TNTV as a member of the genus Orthobunyavirus, family Peribunyaviridae.

Original languageEnglish (US)
Article number001196
Pages (from-to)137-144
Number of pages8
JournalJournal of General Virology
Volume100
Issue number2
DOIs
StatePublished - Feb 2019

Keywords

  • Arbovirus
  • Peribunyaviridae
  • Phylogenetic analysis
  • Serologic tests
  • Triniti virus
  • Ultrastructure

ASJC Scopus subject areas

  • Virology

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    Lima, J. A., Neto, J. P. N., Castro, K. S., da Rosa, A. P. D. A. T., Tesh, R., Nunes, M. R. T., Popov, V. L., Vasilakis, N., Guzman, H., Widen, S., da Silva, S. P., Medeiros, D. B. D. A., Cardoso, J. F., Martins, L. C., Azevedo, R. D. S. D. S., Vasconcelos, P. F. D. C., & Chiang, J. O. (2019). Characterization of triniti virus supports its reclassification in the family peribunyaviridae. Journal of General Virology, 100(2), 137-144. [001196]. https://doi.org/10.1099/jgv.0.001196