Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C

David A. Litvak, Hideaki Iseki, B. Mark Evers, George H Greeley, Mark R. Hellmich, Kazuhiro Iwase, Ambikaipakan Balasubramaniam, Courtney M. Townsend

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalDigestive Diseases and Sciences
Volume44
Issue number3
DOIs
StatePublished - Jan 1 1999

Keywords

  • Intestinal absorption
  • PYY analog
  • Peptide YY
  • Proabsorptive agent

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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