Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C

David A. Litvak, Hideaki Iseki, B. Mark Evers, George H. Greeley, Mark Hellmich, Kazuhiro Iwase, Ambikaipakan Balasubramaniam, Courtney Townsend

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalDigestive Diseases and Sciences
Volume44
Issue number3
StatePublished - 1999

Fingerprint

Peptide YY
Intestinal Absorption
Water
Sodium
Short Bowel Syndrome
Cholera
BIM 43073D
Crohn Disease
Electrolytes
Fistula
Animal Models
Hormones
Dogs

Keywords

  • Intestinal absorption
  • Peptide YY
  • Proabsorptive agent
  • PYY analog

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C. / Litvak, David A.; Iseki, Hideaki; Evers, B. Mark; Greeley, George H.; Hellmich, Mark; Iwase, Kazuhiro; Balasubramaniam, Ambikaipakan; Townsend, Courtney.

In: Digestive Diseases and Sciences, Vol. 44, No. 3, 1999, p. 643-648.

Research output: Contribution to journalArticle

Litvak, DA, Iseki, H, Evers, BM, Greeley, GH, Hellmich, M, Iwase, K, Balasubramaniam, A & Townsend, C 1999, 'Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C', Digestive Diseases and Sciences, vol. 44, no. 3, pp. 643-648.
Litvak, David A. ; Iseki, Hideaki ; Evers, B. Mark ; Greeley, George H. ; Hellmich, Mark ; Iwase, Kazuhiro ; Balasubramaniam, Ambikaipakan ; Townsend, Courtney. / Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C. In: Digestive Diseases and Sciences. 1999 ; Vol. 44, No. 3. pp. 643-648.
@article{2e957ad784c44bad9d10866f9a8c4379,
title = "Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C",
abstract = "Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.",
keywords = "Intestinal absorption, Peptide YY, Proabsorptive agent, PYY analog",
author = "Litvak, {David A.} and Hideaki Iseki and Evers, {B. Mark} and Greeley, {George H.} and Mark Hellmich and Kazuhiro Iwase and Ambikaipakan Balasubramaniam and Courtney Townsend",
year = "1999",
language = "English (US)",
volume = "44",
pages = "643--648",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C

AU - Litvak, David A.

AU - Iseki, Hideaki

AU - Evers, B. Mark

AU - Greeley, George H.

AU - Hellmich, Mark

AU - Iwase, Kazuhiro

AU - Balasubramaniam, Ambikaipakan

AU - Townsend, Courtney

PY - 1999

Y1 - 1999

N2 - Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.

AB - Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.

KW - Intestinal absorption

KW - Peptide YY

KW - Proabsorptive agent

KW - PYY analog

UR - http://www.scopus.com/inward/record.url?scp=0033049952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033049952&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 643

EP - 648

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 3

ER -