Chemical shift imaging of mannitol in acute cerebral ischemia: Case report

Anthony V. Maioriello, Gregory Chaljub, Haring J W Nauta, Michel Lacroix

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effectiveness of mannitol for the treatment of cerebral edema after stroke has long been debated, and the diffusion of mannitol through a disrupted blood-brain barrier has been the focus of many contradictory studies. The authors present a unique case in which chemical shift imaging was used to demonstrate the accumulation of mannitol in an area of stroke underlying a subdural hematoma in a patient with end-stage renal disease being treated with hemodialysis. A metabolite map for the xenobiotic mannitol was created from the data and demonstrated the accumulation of mannitol when hemodialysis was interrupted prematurely. Metabolite maps were also used to show removal of the mannitol with the reestablishment of hemodialysis. It is concluded that mannitol can accumulate in an area of infarction, and that chemical shift imaging can be used to illustrate this process.

Original languageEnglish (US)
Pages (from-to)687-691
Number of pages5
JournalJournal of Neurosurgery
Volume97
Issue number3
StatePublished - Sep 2002

Fingerprint

Mannitol
Brain Ischemia
Magnetic Resonance Imaging
Renal Dialysis
Stroke
Subdural Hematoma
Brain Edema
Xenobiotics
Blood-Brain Barrier
Infarction
Chronic Kidney Failure

Keywords

  • Chemical shift imaging
  • Magnetic resonance spectroscopy
  • Mannitol
  • Stroke
  • Subdural hematoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Maioriello, A. V., Chaljub, G., Nauta, H. J. W., & Lacroix, M. (2002). Chemical shift imaging of mannitol in acute cerebral ischemia: Case report. Journal of Neurosurgery, 97(3), 687-691.

Chemical shift imaging of mannitol in acute cerebral ischemia : Case report. / Maioriello, Anthony V.; Chaljub, Gregory; Nauta, Haring J W; Lacroix, Michel.

In: Journal of Neurosurgery, Vol. 97, No. 3, 09.2002, p. 687-691.

Research output: Contribution to journalArticle

Maioriello, AV, Chaljub, G, Nauta, HJW & Lacroix, M 2002, 'Chemical shift imaging of mannitol in acute cerebral ischemia: Case report', Journal of Neurosurgery, vol. 97, no. 3, pp. 687-691.
Maioriello AV, Chaljub G, Nauta HJW, Lacroix M. Chemical shift imaging of mannitol in acute cerebral ischemia: Case report. Journal of Neurosurgery. 2002 Sep;97(3):687-691.
Maioriello, Anthony V. ; Chaljub, Gregory ; Nauta, Haring J W ; Lacroix, Michel. / Chemical shift imaging of mannitol in acute cerebral ischemia : Case report. In: Journal of Neurosurgery. 2002 ; Vol. 97, No. 3. pp. 687-691.
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