Chemoattractant factors in breast milk from allergic and nonallergic mothers

Malin F. Böttcher, Maria C. Jenmalm, Bengt Björkstén, Roberto Garofalo

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The allergy-preventing effect of breast-feeding remains controversial, possibly because of individual variations in the composition of the breast milk. Recently, we showed that allergic mothers had higher concentrations of IL-4 and lower concentrations of ovalbumin-specific IgA in their breast milk than nonallergic mothers. The aim of this study was to investigate the concentrations of chemokines and cytokines that are chemotactic to cells involved in allergic reactions in breast milk from allergic and nonallergic mothers. Cytokine and chemokine concentrations were determined with ELISA in colostrum and mature milk samples from 23 mothers with and 25 mothers without atopic symptoms. IL-8 was detected in all milk samples. RANTES (regulated on activation, normal T cell expressed and secreted), eotaxin, and IL-16 were detected in 50%, 76%, and 48%, respectively, in colostrum and less commonly in mature milk. Macrophage inflammatory protein-1α, however, could not be detected in any of the samples. The concentrations of IL-8 and RANTES were higher in breast milk from allergic, compared with nonallergic, mothers. In conclusion, the presence of chemoattractant factors in breast milk may be responsible for the traffic of leukocytes from the maternal circulation to the breast milk. The higher concentrations of RANTES and IL-8 in allergic mothers may partly explain the controversy regarding the protective effect of breast-feeding against the development of allergy by stronger chemotaxis and activation of cells involved in allergic diseases, and possibly by elevated IgE production.

Original languageEnglish (US)
Pages (from-to)592-597
Number of pages6
JournalPediatric Research
Volume47
Issue number5
StatePublished - May 2000

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Chemotactic Factors
Human Milk
Interleukin-8
Chemokines
Hypersensitivity
Milk
Colostrum
Breast Feeding
T-Lymphocytes
Interleukin-16
Macrophage Inflammatory Proteins
Ovalbumin
Chemotaxis
Interleukin-4
Immunoglobulin A
Immunoglobulin E
Leukocytes
Enzyme-Linked Immunosorbent Assay
Mothers
Cytokines

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Böttcher, M. F., Jenmalm, M. C., Björkstén, B., & Garofalo, R. (2000). Chemoattractant factors in breast milk from allergic and nonallergic mothers. Pediatric Research, 47(5), 592-597.

Chemoattractant factors in breast milk from allergic and nonallergic mothers. / Böttcher, Malin F.; Jenmalm, Maria C.; Björkstén, Bengt; Garofalo, Roberto.

In: Pediatric Research, Vol. 47, No. 5, 05.2000, p. 592-597.

Research output: Contribution to journalArticle

Böttcher, MF, Jenmalm, MC, Björkstén, B & Garofalo, R 2000, 'Chemoattractant factors in breast milk from allergic and nonallergic mothers', Pediatric Research, vol. 47, no. 5, pp. 592-597.
Böttcher, Malin F. ; Jenmalm, Maria C. ; Björkstén, Bengt ; Garofalo, Roberto. / Chemoattractant factors in breast milk from allergic and nonallergic mothers. In: Pediatric Research. 2000 ; Vol. 47, No. 5. pp. 592-597.
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