Chemoradiation followed by chemotherapy before resection for borderline pancreatic adenocarcinoma

Kimberly M. Brown, Veeriah Siripurapu, Marson Davidson, Steven J. Cohen, Andre Konski, James C. Watson, Tiaynu Li, Vince Ciocca, Harry Cooper, John P. Hoffman

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Background: For patients with borderline resectable pancreatic cancer, preoperative chemoradiation and standalone chemotherapy may allow for R0 resection and improved survival. Methods: A retrospective review of patients with borderline resectable pancreatic cancer treated with preoperative chemoradiation and standalone chemotherapy was undertaken. Clinical variables, including disease-free and overall survival, were collected. Univariate analysis was used to identify factors impacting survival. Results: Thirteen patients with borderline resectable pancreatic cancer were treated with preoperative chemoradiation and chemotherapy. Morbidity and mortality were 38% and 0. There were 2 R1 and 11 R0 resections. Nine patients are alive with a median follow-up of 20 months. Five patients recurred at a median of 4 months. Tumor fibrosis ≤60% was associated with recurrence and poor survival. Conclusions: Preoperative chemoradiation and chemotherapy allow a select group of patients with borderline resectable pancreatic cancer to undergo an R0 or R1 resection with acceptable morbidity and mortality. Tumor response may be associated with survival.

Original languageEnglish (US)
Pages (from-to)318-321
Number of pages4
JournalAmerican Journal of Surgery
Volume195
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Borderline resectable
  • Cancer
  • Chemoradiation
  • Chemotherapy
  • Neoadjuvant
  • Pancreas
  • Pancreatic cancer

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Brown, K. M., Siripurapu, V., Davidson, M., Cohen, S. J., Konski, A., Watson, J. C., Li, T., Ciocca, V., Cooper, H., & Hoffman, J. P. (2008). Chemoradiation followed by chemotherapy before resection for borderline pancreatic adenocarcinoma. American Journal of Surgery, 195(3), 318-321. https://doi.org/10.1016/j.amjsurg.2007.12.017