Chikungunya: Evolutionary history and recent epidemic spread

Scott Weaver, Naomi L. Forrester

Research output: Contribution to journalArticle

173 Scopus citations

Abstract

Chikungunya virus (CHIKV) has a long history of emergence into urban transmission cycles from its ancestral, enzootic, sylvatic foci in Sub-Saharan Africa, most recently spreading to the Americas beginning in 2013. Since 2004, reemergence has resulted in millions of cases of severe, debilitating and often chronic arthralgia on five continents. Here, we review this history based on phylogenetic studies, and discuss probable future spread and disease in the Americas. We also discuss a series of mutations in the recently emerged Indian Ocean Lineage that has adapted the virus for transmission for the first time by the Aedes albopictus urban mosquito vector, and compare CHIKV to other arboviruses with and without similar histories of urbanization. This article forms part of a symposium in Antiviral Research on Chikungunya discovers the New World.

Original languageEnglish (US)
Pages (from-to)32-39
Number of pages8
JournalAntiviral Research
Volume120
DOIs
StatePublished - Aug 1 2015

Keywords

  • Alphavirus
  • Arbovirus
  • Arthralgia
  • Chikungunya
  • Mosquito
  • Urbanization

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Fingerprint Dive into the research topics of 'Chikungunya: Evolutionary history and recent epidemic spread'. Together they form a unique fingerprint.

  • Cite this