Chikungunya virus

Evolution and genetic determinants of emergence

Konstantin A. Tsetsarkin, Rubing Chen, Michael Sherman, Scott Weaver

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Chikungunya virus (CHIKV) causes a severe and often persistent arthralgic disease that is occasionally fatal. A mosquito-borne virus, CHIKV exists in enzootic, nonhuman primate cycles in Africa, but occasionally emerges into urban, human cycles to cause major epidemics. Between 1920 and 1950, and again in 2005, CHIKV emerged into India and Southeast Asia, where major urban epidemics ensued. Unlike the early introduction, the 2005 emergence was accompanied by an adaptive mutation that allowed CHIKV to exploit a new epidemic vector, Aedes albopictus, via an A226V substitution in the E1 envelope glycoprotein. However, recent reverse genetic studies indicate that lineage-specific epistatic restrictions can prevent this from exerting its phenotype on mosquito infectivity. Thus, the A. albopictus-adaptive A226V substitution that is facilitating the dramatic geographic spread of CHIKV epidemics was prevented for decades or longer from being selected in most African enzootic strains as well as in the older endemic Asian lineage.

Original languageEnglish (US)
Pages (from-to)310-317
Number of pages8
JournalCurrent Opinion in Virology
Volume1
Issue number4
DOIs
StatePublished - Oct 2011

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Chikungunya virus
Molecular Evolution
Culicidae
Reverse Genetics
Southeastern Asia
Aedes
Primates
India
Glycoproteins
Viruses
Phenotype
Mutation

ASJC Scopus subject areas

  • Virology

Cite this

Chikungunya virus : Evolution and genetic determinants of emergence. / Tsetsarkin, Konstantin A.; Chen, Rubing; Sherman, Michael; Weaver, Scott.

In: Current Opinion in Virology, Vol. 1, No. 4, 10.2011, p. 310-317.

Research output: Contribution to journalArticle

Tsetsarkin, Konstantin A. ; Chen, Rubing ; Sherman, Michael ; Weaver, Scott. / Chikungunya virus : Evolution and genetic determinants of emergence. In: Current Opinion in Virology. 2011 ; Vol. 1, No. 4. pp. 310-317.
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