Childhood Depression

Pharmacological Therapy/Treatment (Pharmacotherapy of Childhood Depression)

Karen Wagner, Paul J. Ambrosini

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Critiqued the published double-blind, placebo-controlled studies of antidepressant pharmacotherapy in child and adolescent major depressive disorder to assess their overall efficacy. The pharmacological mechanism of antidepressant action also was discussed. At best, antidepressant treatment for depressed youths is only modestly effective. In particular, the tricyclic antidepressants are not superior to placebo; however, early evidence with the selective serotonin reuptake inhibitors is more encouraging. The theoretical basis for this response pattern is discussed from a methodological perspective, from a neurodevelopmental status, and from a biological viewpoint. Study modifications are suggested which could improve some of the methodological limitations apparent in previous clinical drug trials.

Original languageEnglish (US)
Pages (from-to)88-97
Number of pages10
JournalJournal of Clinical Child and Adolescent Psychology
Volume30
Issue number1
StatePublished - 2001
Externally publishedYes

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Antidepressive Agents
Pharmacology
Depression
Drug Therapy
Molecular Mechanisms of Pharmacological Action
Placebos
Tricyclic Antidepressive Agents
Major Depressive Disorder
Serotonin Uptake Inhibitors
Therapeutics
Clinical Trials
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychology(all)
  • Clinical Psychology
  • Developmental and Educational Psychology

Cite this

Childhood Depression : Pharmacological Therapy/Treatment (Pharmacotherapy of Childhood Depression). / Wagner, Karen; Ambrosini, Paul J.

In: Journal of Clinical Child and Adolescent Psychology, Vol. 30, No. 1, 2001, p. 88-97.

Research output: Contribution to journalArticle

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