Childhood gastroparesis is a unique entity in need of further investigation

Liz Febo-Rodriguez, Bruno P. Chumpitazi, Robert J. Shulman

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Background: Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP-specific pediatric reported outcome measures. Purpose: The aim of this article was to review the available literature on pediatric GP and identify similarities and differences with studies in adults. We performed a comprehensive search in MEDLINE and Google Scholar from inception to April 2019 for articles published in English using the following combination of keywords: gastroparesis, pediatric gastroparesis, outcomes, metoclopramide, erythromycin, domperidone, cisapride, and gastric neurostimulator. The limited available pediatric data, often retrospective, suggest marked differences between adult and pediatric GP in several aspects including etiology, concomitant co-morbidities (eg, psychiatric disorders), clinical symptom presentation, diagnostic evaluation, response to therapies, and clinical outcome. Further research in pediatric GP is needed and holds the promise to further elucidate the mechanisms of this disorder in children and lead to pediatric-focused therapies.

Original languageEnglish (US)
Article numbere13699
JournalNeurogastroenterology and Motility
Volume32
Issue number3
DOIs
StatePublished - Mar 1 2020
Externally publishedYes

Keywords

  • gastric emptying
  • gastroparesis
  • motility
  • pediatric gastroenterology

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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