Children with severe burns display no sex differences in exercise capacity at hospital discharge or adaptation after exercise rehabilitation training

Eric Rivas, David Herndon, Martha L. Chapa, Janos Cambiaso-Daniel, Victoria G. Rontoyanni, Ileana L. Gutierrez, Kevin Sanchez, Shauna Glover, Oscar Suman

Research output: Contribution to journalArticle

Abstract

Background and objective: Females have a 50% increased risk of death from burn injury compared to males. However, whether exercise capacity and exercise induced training adaptations differ between burned boys and girls is unknown. This project tested the hypothesis that girls with burns have lower exercise capacity and different exercise induced training adaptations. Methods: Twenty-five girls were matched to 26 boys (mean, 95%CI; years 13 [12,14], cm 151 [143,161], kg 54 [45,63]; each P> 0.05) for burn injury (% total body surface area burn, 54 [45,62]; P =0.82). Lean body mass (LBM), strength (peak torque) and cardiorespiratory fitness (peak VO2) were normalized to kg LBM and compared as a percentage of age-sex matched non-burned children (n=26 boys, years 13 [12,14]; n=25 girls, years 13 [12,14]) at discharge (DC) and after aerobic and resistance rehabilitation exercise training (RET). Results: Using a 2-way factorial ANOVA (group×time), we found both groups had similar 11% change in LBM (87.3% of non-burned values [82.2,92.3]) and after the RET (92.8% [87.2,98.3]; main effect, time P< 0.0001). Peak torque increased similarly by 16% in both groups (% of age-sex matched non-burned DC, 55.9 [51.3,60.5]; after RET, 77.5 [72.1,82.9]; main effect, time P< 0.0001). Likewise, peak VO2 increased in both groups by 15% (% of age-sex matched non-burned DC, 56.8 [52.4,61.2] to RET, 72.2 [67.6,76.8]; main effect, time; P <0.0001). Burned children exercise at greater percentage of their peak VO2 and peak HR compared to non-burned children (Interaction, group×time, P <0.0001). Conclusion: The burn injury does not have sex-dependent effects on LBM or exercise capacity in severely burn injured children. Differences in relative peak VO2 and peak HR suggest the need for burn specific exercise programs for improving the efficacy of a rehabilitation program.

Original languageEnglish (US)
JournalBurns
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Burns
Sex Characteristics
Exercise
Exercise Therapy
Torque
Wounds and Injuries
Age Groups
Body Surface Area
Analysis of Variance
Rehabilitation

Keywords

  • Aerobic
  • Body composition
  • Burn trauma
  • Gender difference
  • Strength

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Children with severe burns display no sex differences in exercise capacity at hospital discharge or adaptation after exercise rehabilitation training. / Rivas, Eric; Herndon, David; Chapa, Martha L.; Cambiaso-Daniel, Janos; Rontoyanni, Victoria G.; Gutierrez, Ileana L.; Sanchez, Kevin; Glover, Shauna; Suman, Oscar.

In: Burns, 01.01.2018.

Research output: Contribution to journalArticle

Rivas, Eric ; Herndon, David ; Chapa, Martha L. ; Cambiaso-Daniel, Janos ; Rontoyanni, Victoria G. ; Gutierrez, Ileana L. ; Sanchez, Kevin ; Glover, Shauna ; Suman, Oscar. / Children with severe burns display no sex differences in exercise capacity at hospital discharge or adaptation after exercise rehabilitation training. In: Burns. 2018.
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abstract = "Background and objective: Females have a 50{\%} increased risk of death from burn injury compared to males. However, whether exercise capacity and exercise induced training adaptations differ between burned boys and girls is unknown. This project tested the hypothesis that girls with burns have lower exercise capacity and different exercise induced training adaptations. Methods: Twenty-five girls were matched to 26 boys (mean, 95{\%}CI; years 13 [12,14], cm 151 [143,161], kg 54 [45,63]; each P> 0.05) for burn injury ({\%} total body surface area burn, 54 [45,62]; P =0.82). Lean body mass (LBM), strength (peak torque) and cardiorespiratory fitness (peak VO2) were normalized to kg LBM and compared as a percentage of age-sex matched non-burned children (n=26 boys, years 13 [12,14]; n=25 girls, years 13 [12,14]) at discharge (DC) and after aerobic and resistance rehabilitation exercise training (RET). Results: Using a 2-way factorial ANOVA (group×time), we found both groups had similar 11{\%} change in LBM (87.3{\%} of non-burned values [82.2,92.3]) and after the RET (92.8{\%} [87.2,98.3]; main effect, time P< 0.0001). Peak torque increased similarly by 16{\%} in both groups ({\%} of age-sex matched non-burned DC, 55.9 [51.3,60.5]; after RET, 77.5 [72.1,82.9]; main effect, time P< 0.0001). Likewise, peak VO2 increased in both groups by 15{\%} ({\%} of age-sex matched non-burned DC, 56.8 [52.4,61.2] to RET, 72.2 [67.6,76.8]; main effect, time; P <0.0001). Burned children exercise at greater percentage of their peak VO2 and peak HR compared to non-burned children (Interaction, group×time, P <0.0001). Conclusion: The burn injury does not have sex-dependent effects on LBM or exercise capacity in severely burn injured children. Differences in relative peak VO2 and peak HR suggest the need for burn specific exercise programs for improving the efficacy of a rehabilitation program.",
keywords = "Aerobic, Body composition, Burn trauma, Gender difference, Strength",
author = "Eric Rivas and David Herndon and Chapa, {Martha L.} and Janos Cambiaso-Daniel and Rontoyanni, {Victoria G.} and Gutierrez, {Ileana L.} and Kevin Sanchez and Shauna Glover and Oscar Suman",
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T1 - Children with severe burns display no sex differences in exercise capacity at hospital discharge or adaptation after exercise rehabilitation training

AU - Rivas, Eric

AU - Herndon, David

AU - Chapa, Martha L.

AU - Cambiaso-Daniel, Janos

AU - Rontoyanni, Victoria G.

AU - Gutierrez, Ileana L.

AU - Sanchez, Kevin

AU - Glover, Shauna

AU - Suman, Oscar

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background and objective: Females have a 50% increased risk of death from burn injury compared to males. However, whether exercise capacity and exercise induced training adaptations differ between burned boys and girls is unknown. This project tested the hypothesis that girls with burns have lower exercise capacity and different exercise induced training adaptations. Methods: Twenty-five girls were matched to 26 boys (mean, 95%CI; years 13 [12,14], cm 151 [143,161], kg 54 [45,63]; each P> 0.05) for burn injury (% total body surface area burn, 54 [45,62]; P =0.82). Lean body mass (LBM), strength (peak torque) and cardiorespiratory fitness (peak VO2) were normalized to kg LBM and compared as a percentage of age-sex matched non-burned children (n=26 boys, years 13 [12,14]; n=25 girls, years 13 [12,14]) at discharge (DC) and after aerobic and resistance rehabilitation exercise training (RET). Results: Using a 2-way factorial ANOVA (group×time), we found both groups had similar 11% change in LBM (87.3% of non-burned values [82.2,92.3]) and after the RET (92.8% [87.2,98.3]; main effect, time P< 0.0001). Peak torque increased similarly by 16% in both groups (% of age-sex matched non-burned DC, 55.9 [51.3,60.5]; after RET, 77.5 [72.1,82.9]; main effect, time P< 0.0001). Likewise, peak VO2 increased in both groups by 15% (% of age-sex matched non-burned DC, 56.8 [52.4,61.2] to RET, 72.2 [67.6,76.8]; main effect, time; P <0.0001). Burned children exercise at greater percentage of their peak VO2 and peak HR compared to non-burned children (Interaction, group×time, P <0.0001). Conclusion: The burn injury does not have sex-dependent effects on LBM or exercise capacity in severely burn injured children. Differences in relative peak VO2 and peak HR suggest the need for burn specific exercise programs for improving the efficacy of a rehabilitation program.

AB - Background and objective: Females have a 50% increased risk of death from burn injury compared to males. However, whether exercise capacity and exercise induced training adaptations differ between burned boys and girls is unknown. This project tested the hypothesis that girls with burns have lower exercise capacity and different exercise induced training adaptations. Methods: Twenty-five girls were matched to 26 boys (mean, 95%CI; years 13 [12,14], cm 151 [143,161], kg 54 [45,63]; each P> 0.05) for burn injury (% total body surface area burn, 54 [45,62]; P =0.82). Lean body mass (LBM), strength (peak torque) and cardiorespiratory fitness (peak VO2) were normalized to kg LBM and compared as a percentage of age-sex matched non-burned children (n=26 boys, years 13 [12,14]; n=25 girls, years 13 [12,14]) at discharge (DC) and after aerobic and resistance rehabilitation exercise training (RET). Results: Using a 2-way factorial ANOVA (group×time), we found both groups had similar 11% change in LBM (87.3% of non-burned values [82.2,92.3]) and after the RET (92.8% [87.2,98.3]; main effect, time P< 0.0001). Peak torque increased similarly by 16% in both groups (% of age-sex matched non-burned DC, 55.9 [51.3,60.5]; after RET, 77.5 [72.1,82.9]; main effect, time P< 0.0001). Likewise, peak VO2 increased in both groups by 15% (% of age-sex matched non-burned DC, 56.8 [52.4,61.2] to RET, 72.2 [67.6,76.8]; main effect, time; P <0.0001). Burned children exercise at greater percentage of their peak VO2 and peak HR compared to non-burned children (Interaction, group×time, P <0.0001). Conclusion: The burn injury does not have sex-dependent effects on LBM or exercise capacity in severely burn injured children. Differences in relative peak VO2 and peak HR suggest the need for burn specific exercise programs for improving the efficacy of a rehabilitation program.

KW - Aerobic

KW - Body composition

KW - Burn trauma

KW - Gender difference

KW - Strength

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