@article{bfc5bab5d03b4b688d0f8ef41e6f4bb1,
title = "Chiral diene-promoted room temperature conjugate arylation: Highly enantioselective synthesis of substituted chiral phenylalanine derivatives and α,α-di(arylmethyl)acetates",
abstract = "A highly enantiocontrolled room temperature rhodium-catalyzed conjugate arylation process was developed. The reaction proceeds through 1,4-addition of α-substituted acrylates followed by enantioselective protonation using a C1-symmetric chiral bicyclo[2,2,2] diene as the ligand and water as the proton source. This exceptionally simple protocol provides a reliable and practical access to structurally important phenylalanine derivatives and α,α-di(arylmethyl)acetates in high yields (up to 99%) with good to excellent ee values (up to 99%).",
author = "Chen, {Jian Ping} and Xu, {Ming Hua} and Xu, {Ming Hua}",
note = "Funding Information: We thank the National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program”, China (2018ZX09711002-006), the National Natural Science Foundation of China (21971103, 21672229, and 81521005) and the Shenzhen Science and Technology Innovation Committee (ZDSYS20190902093215877) for financial support. We are especially grateful to Dr Stefan Abele in Idorsia Pharmaceuticals Ltd, Switzerland for his very generous donation of the key intermediate (1R,4R)-5-phenylbicyclo[2.2.2] oct-5-en-2-one for diene preparation. Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",
year = "2020",
month = jun,
day = "28",
doi = "10.1039/d0ob00616e",
language = "English (US)",
volume = "18",
pages = "4569--4574",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "24",
}