TY - JOUR
T1 - Chlamydial genovar distribution after communitywide antibiotic treatment
AU - Bain, Deborah L.
AU - Lietman, Thomas
AU - Rasmussen, Stephanie
AU - Kalman, Sue
AU - Fan, Jun
AU - Lammel, Claudia
AU - Zhang, Jian Zhi
AU - Dawson, Chandler R.
AU - Schachter, Julius
AU - Stephens, Richard S.
N1 - Funding Information:
Received 6 November 2000; revised 31 July 2001; electronically published 3 December 2001. Financial support: National Institutes of Health (AI-48789 and EY-07757). Reprints or correspondence: Dr. Richard S. Stephens, Div. of Infectious Diseases, 235 Earl Warren Hall, University of California, Berkeley, CA 94720-7360 ([email protected]).
PY - 2001/12/15
Y1 - 2001/12/15
N2 - Major outer membrane protein sequences, determined from Chlamydia-positive eye swab samples collected in 2 Egyptian villages, were used to analyze the epidemiology of trachoma in an endemic setting. Samples were collected during the 1999 Azithromycin in Control of Trachoma trial, in which residents of villages were mass treated with either oral azithromycin or topical tetracycline and were followed up for nearly 2 years. Three genovar families (A, Ba, and C) and 12 genovars were detected, with 2 genovars (A1 and Ba1) comprising almost 75% of the samples. The presence of > 1 genovar within households was common, with ≥24% of households having > 1 genovar. Evidence consistent with reinfection and persistence as mechanisms of communitywide continued presence of trachoma was provided by data for individuals infected with rare genovars.
AB - Major outer membrane protein sequences, determined from Chlamydia-positive eye swab samples collected in 2 Egyptian villages, were used to analyze the epidemiology of trachoma in an endemic setting. Samples were collected during the 1999 Azithromycin in Control of Trachoma trial, in which residents of villages were mass treated with either oral azithromycin or topical tetracycline and were followed up for nearly 2 years. Three genovar families (A, Ba, and C) and 12 genovars were detected, with 2 genovars (A1 and Ba1) comprising almost 75% of the samples. The presence of > 1 genovar within households was common, with ≥24% of households having > 1 genovar. Evidence consistent with reinfection and persistence as mechanisms of communitywide continued presence of trachoma was provided by data for individuals infected with rare genovars.
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U2 - 10.1086/324661
DO - 10.1086/324661
M3 - Article
C2 - 11740734
AN - SCOPUS:0035892797
SN - 0022-1899
VL - 184
SP - 1581
EP - 1588
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -