Chlamydial genovar distribution after communitywide antibiotic treatment

Deborah L. Bain, Thomas Lietman, Stephanie Rasmussen, Sue Kalman, Jun Fan, Claudia Lammel, Jian Zhi Zhang, Chandler R. Dawson, Julius Schachter, Richard S. Stephens

    Research output: Contribution to journalArticle

    16 Scopus citations

    Abstract

    Major outer membrane protein sequences, determined from Chlamydia-positive eye swab samples collected in 2 Egyptian villages, were used to analyze the epidemiology of trachoma in an endemic setting. Samples were collected during the 1999 Azithromycin in Control of Trachoma trial, in which residents of villages were mass treated with either oral azithromycin or topical tetracycline and were followed up for nearly 2 years. Three genovar families (A, Ba, and C) and 12 genovars were detected, with 2 genovars (A1 and Ba1) comprising almost 75% of the samples. The presence of > 1 genovar within households was common, with ≥24% of households having > 1 genovar. Evidence consistent with reinfection and persistence as mechanisms of communitywide continued presence of trachoma was provided by data for individuals infected with rare genovars.

    Original languageEnglish (US)
    Pages (from-to)1581-1588
    Number of pages8
    JournalJournal of Infectious Diseases
    Volume184
    Issue number12
    DOIs
    StatePublished - Dec 15 2001

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Infectious Diseases

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  • Cite this

    Bain, D. L., Lietman, T., Rasmussen, S., Kalman, S., Fan, J., Lammel, C., Zhang, J. Z., Dawson, C. R., Schachter, J., & Stephens, R. S. (2001). Chlamydial genovar distribution after communitywide antibiotic treatment. Journal of Infectious Diseases, 184(12), 1581-1588. https://doi.org/10.1086/324661