Chlamydial genovar distribution after communitywide antibiotic treatment

D. L. Bain, T. Lietman, S. Rasmussen, S. Kalman, J. Fan, C. Lammel, Jianzhi Zhang, C. R. Dawson, J. Schachter, R. S. Stephens

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Major outer membrane protein sequences, determined from Chlamydia-positive eye swab samples collected in 2 Egyptian villages, were used to analyze the epidemiology of trachoma in an endemic setting. Samples were collected during the 1999 Azithromycin in Control of Trachoma trial, in which residents of villages were mass treated with either oral azithromycin or topical tetracycline and were followed up for nearly 2 years. Three genovar families (A, Ba, and C) and 12 genovars were detected, with 2 genovars (A1 and Ba1) comprising almost 75% of the samples. The presence of > 1 genovar within households was common, with ≥24% of households having > 1 genovar. Evidence consistent with reinfection and persistence as mechanisms of communitywide continued presence of trachoma was provided by data for individuals infected with rare genovars.

Original languageEnglish (US)
Pages (from-to)1581-1588
Number of pages8
JournalJournal of Infectious Diseases
Volume184
Issue number12
DOIs
StatePublished - Dec 15 2001
Externally publishedYes

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Trachoma
Azithromycin
Anti-Bacterial Agents
Chlamydia
Tetracycline
Membrane Proteins
Epidemiology

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Bain, D. L., Lietman, T., Rasmussen, S., Kalman, S., Fan, J., Lammel, C., ... Stephens, R. S. (2001). Chlamydial genovar distribution after communitywide antibiotic treatment. Journal of Infectious Diseases, 184(12), 1581-1588. https://doi.org/10.1086/324661

Chlamydial genovar distribution after communitywide antibiotic treatment. / Bain, D. L.; Lietman, T.; Rasmussen, S.; Kalman, S.; Fan, J.; Lammel, C.; Zhang, Jianzhi; Dawson, C. R.; Schachter, J.; Stephens, R. S.

In: Journal of Infectious Diseases, Vol. 184, No. 12, 15.12.2001, p. 1581-1588.

Research output: Contribution to journalArticle

Bain, DL, Lietman, T, Rasmussen, S, Kalman, S, Fan, J, Lammel, C, Zhang, J, Dawson, CR, Schachter, J & Stephens, RS 2001, 'Chlamydial genovar distribution after communitywide antibiotic treatment', Journal of Infectious Diseases, vol. 184, no. 12, pp. 1581-1588. https://doi.org/10.1086/324661
Bain DL, Lietman T, Rasmussen S, Kalman S, Fan J, Lammel C et al. Chlamydial genovar distribution after communitywide antibiotic treatment. Journal of Infectious Diseases. 2001 Dec 15;184(12):1581-1588. https://doi.org/10.1086/324661
Bain, D. L. ; Lietman, T. ; Rasmussen, S. ; Kalman, S. ; Fan, J. ; Lammel, C. ; Zhang, Jianzhi ; Dawson, C. R. ; Schachter, J. ; Stephens, R. S. / Chlamydial genovar distribution after communitywide antibiotic treatment. In: Journal of Infectious Diseases. 2001 ; Vol. 184, No. 12. pp. 1581-1588.
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