Chloroquine inhibition of cholera toxin

Yi fan Liang, Johnny Peterson, Christopher A. Jackson, James C. Reitmeyer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cholera toxin (CT) stimulated adenylate cyclase and a phospholipase which elevated levels of 3.5-cyclic adenosine monophosphate (cAMP) and arachidonic acid (AA). The AA was quickly converted to prostaglandins (PGs) via the cyclo-oxygenase pathway. Chloroquine exerted minimal inhibition of cAMP levels in CT-treated cells, although CT-induced release of [3H]AA and PGs was blocked completely when the drug was added in concentrations as low as 0.1 mM (30 μγ ml). Inhibition of [3H]AA release was complete when chloroquine was added before or within 30 min after CT. The capacity of chloroquine to inhibit either phospholipase C (PLC) or phospholipase A2 (PLA2) could explain the antisecretory activity of this drug.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalFEBS Letters
Volume275
Issue number1-2
DOIs
StatePublished - Nov 26 1990

Fingerprint

Cholera Toxin
Chloroquine
Arachidonic Acid
Cyclic AMP
Prostaglandins
Phospholipases
Phospholipases A2
Type C Phospholipases
Prostaglandin-Endoperoxide Synthases
Adenylyl Cyclases
Pharmaceutical Preparations
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Liang, Y. F., Peterson, J., Jackson, C. A., & Reitmeyer, J. C. (1990). Chloroquine inhibition of cholera toxin. FEBS Letters, 275(1-2), 143-145. https://doi.org/10.1016/0014-5793(90)81459-2

Chloroquine inhibition of cholera toxin. / Liang, Yi fan; Peterson, Johnny; Jackson, Christopher A.; Reitmeyer, James C.

In: FEBS Letters, Vol. 275, No. 1-2, 26.11.1990, p. 143-145.

Research output: Contribution to journalArticle

Liang, YF, Peterson, J, Jackson, CA & Reitmeyer, JC 1990, 'Chloroquine inhibition of cholera toxin', FEBS Letters, vol. 275, no. 1-2, pp. 143-145. https://doi.org/10.1016/0014-5793(90)81459-2
Liang, Yi fan ; Peterson, Johnny ; Jackson, Christopher A. ; Reitmeyer, James C. / Chloroquine inhibition of cholera toxin. In: FEBS Letters. 1990 ; Vol. 275, No. 1-2. pp. 143-145.
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