Cholera toxin and Salmonella typhimurium induce different cytokine profiles in the gastrointestinal tract

G. R. Klimpel, M. Asuncion, J. Haithcoat, D. W. Niesel

    Research output: Contribution to journalArticlepeer-review

    86 Scopus citations

    Abstract

    Salmonella infection of the gastrointestinal tract (GT) results in fluid secretion and inflammation. In contrast, cholera toxin (CT) induces fluid secretion but no inflammation. Using a murine ligated intestinal loop model, we investigated cytokine production (interleukin-1 [IL-1], IL-2, IL-4, IL-6, IL-10, gamma interferon, and tumor necrosis factor alpha) in the GT following exposure to these agents. Salmonella typhimurium induced a Th1-like cytokine profile in loops obtained from either nonimmune mice or Salmonella-immunized mice. CT induced only IL-6 and IL-10 production in ligated loops from nonimmune mice but induced a Th2-like cytokine profile in ligated loops obtained from CT-immunized mice. These results show that CT and S. typhimurium induce very different cytokine profiles in the GT.

    Original languageEnglish (US)
    Pages (from-to)1134-1137
    Number of pages4
    JournalInfection and immunity
    Volume63
    Issue number3
    DOIs
    StatePublished - 1995

    ASJC Scopus subject areas

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases

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