Cholera toxin and Salmonella typhimurium induce different cytokine profiles in the gastrointestinal tract

G. R. Klimpel, M. Asuncion, J. Haithcoat, D. W. Niesel

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Salmonella infection of the gastrointestinal tract (GT) results in fluid secretion and inflammation. In contrast, cholera toxin (CT) induces fluid secretion but no inflammation. Using a murine ligated intestinal loop model, we investigated cytokine production (interleukin-1 [IL-1], IL-2, IL-4, IL-6, IL-10, gamma interferon, and tumor necrosis factor alpha) in the GT following exposure to these agents. Salmonella typhimurium induced a Th1-like cytokine profile in loops obtained from either nonimmune mice or Salmonella-immunized mice. CT induced only IL-6 and IL-10 production in ligated loops from nonimmune mice but induced a Th2-like cytokine profile in ligated loops obtained from CT-immunized mice. These results show that CT and S. typhimurium induce very different cytokine profiles in the GT.

Original languageEnglish (US)
Pages (from-to)1134-1137
Number of pages4
JournalInfection and immunity
Volume63
Issue number3
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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