Cholesterol in serum lipoprotein fractions after spaceflight

C. S. Leach, P. C. Johnson, J. M. Krauhs, N. M. Cintron

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Cholesterol, triglycerides, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were measured in blood samples from 125 crewmembers on the first 24 space shuttle flights. Samples were obtained before, immediately after, and 3-23 days after spaceflight. On landing day, only HDL-C was significantly changed from its preflight level; it had decreased 12.8%. Later in the postflight period, total cholesterol and LDL-C as well as HDL-C decreased significantly. Possible causes of these decreases in estimated cholesterol content of lipoprotein fractions include increased levels of thyroxine during flight and reduced physical activity. The postflight decrease in HDL-C is not considered to have clinical significance for shuttle astronauts, but lipoproteins and apolipoproteins should be measured in blood drawn during longer missions.

Original languageEnglish (US)
Pages (from-to)1034-1037
Number of pages4
JournalAviation Space and Environmental Medicine
Volume59
Issue number11
StatePublished - Jan 1 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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