Cholesterol, oxidative stress, and Alzheimer's disease: Expanding the horizons of pathogenesis

Miguel A. Pappolla; Mark A. Smith; Tara Bryant-Thomas; Nicolas Bazan; Suzana Petanceska; George Perry; Leon J. Thal; Mary Sano; Lorenzo M. Refolo

doi:10.1016/S0891-5849(02)00841-9

Cholesterol, oxidative stress, and Alzheimer's disease: Expanding the horizons of pathogenesis

Miguel A. Pappolla, Mark A. Smith, Tara Bryant-Thomas, Nicolas Bazan, Suzana Petanceska, George Perry, Leon J. Thal, Mary Sano, Lorenzo M. Refolo

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Recent epidemiological, clinical, and experimental data suggest that cholesterol may play a role in Alzheimer's disease (AD). We have recently shown that cholesterolemia has a profound effect in the development and modulation of amyloid pathology in a transgenic model of AD. This review summarizes recent advancements in our understanding of the potential role of cholesterol and the amyloid β protein in initiating the generation of free radicals and points out their role in a chain of events that causes damage of essential macromolecules in the central nervous system and culminates in neuronal dysfunction and loss. Experimental data links cholesterol and oxidative stress with some neurodegenerative aspects of AD.

Original language	English (US)
Pages (from-to)	173-181
Number of pages	9
Journal	Free Radical Biology and Medicine
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/S0891-5849(02)00841-9
State	Published - Jul 15 2002
Externally published	Yes

Keywords

Alzheimer's disease
Amyloid β peptide
Cholesterol
Free radicals
Neurodegeneration
Neurofibrillary tangles
Oxidative stress

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

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10.1016/S0891-5849(02)00841-9

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title = "Cholesterol, oxidative stress, and Alzheimer's disease: Expanding the horizons of pathogenesis",

abstract = "Recent epidemiological, clinical, and experimental data suggest that cholesterol may play a role in Alzheimer's disease (AD). We have recently shown that cholesterolemia has a profound effect in the development and modulation of amyloid pathology in a transgenic model of AD. This review summarizes recent advancements in our understanding of the potential role of cholesterol and the amyloid β protein in initiating the generation of free radicals and points out their role in a chain of events that causes damage of essential macromolecules in the central nervous system and culminates in neuronal dysfunction and loss. Experimental data links cholesterol and oxidative stress with some neurodegenerative aspects of AD.",

keywords = "Alzheimer's disease, Amyloid β peptide, Cholesterol, Free radicals, Neurodegeneration, Neurofibrillary tangles, Oxidative stress",

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AU - Pappolla, Miguel A.

AU - Smith, Mark A.

AU - Bryant-Thomas, Tara

AU - Bazan, Nicolas

AU - Petanceska, Suzana

AU - Perry, George

AU - Thal, Leon J.

AU - Sano, Mary

AU - Refolo, Lorenzo M.

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KW - Amyloid β peptide

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KW - Neurodegeneration

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Cholesterol, oxidative stress, and Alzheimer's disease: Expanding the horizons of pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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