Cholinergic-adrenergic interactions on intestinal ion transport.

E. J. Tapper, D. W. Powell, S. M. Morris

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The autonomic control of intestinal electrolyte transport has been investigated in the in vitro, short-circuited rabbit ileum with varying doses of carbachol and with neuroeffector blocking agents. Low-dose carbachol (less than 10(-6) M) and high-dose carbachol (greater than 10(-4) M) had different effects on Na and Cl transport. Low-dose carbachol caused a transient increase in the potential difference and short-circult current, stimulated Cl secretion, and inhibited the residual flux (probably HCO3 secretion). This is a muscarinic response since it is inhibited by atropine (10(-6) M). After an initial increase of the potential difference and short-circuit current, high-dose carbachol reduced these electrical parameters, stimulated Na and Cl absorption, and abolished the residual flux. This is a nicotinic response since it is inhibited by hexamethonium (10(-5) M). This nicotinic response is identical to that reported by others with alpha-adrenergic agents and it was inhibited also by phentolamine (10(-7) M). We propose that high-dose carbachol stimulates nicotinic receptors on postganglionic sympathetic fibers present in our preparations causing a release of catecholamines and a resulting alpha-adrenergic response by the intestinal epithelial cell. The physiological significance of this response in the gut remains to be determined.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume235
Issue number4
StatePublished - Oct 1978
Externally publishedYes

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Ion Transport
Carbachol
Adrenergic Agents
Cholinergic Agents
Postganglionic Sympathetic Fibers
Hexamethonium
Phentolamine
Nicotinic Receptors
Atropine
Ileum
Electrolytes
Catecholamines
Epithelial Cells
Rabbits

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cholinergic-adrenergic interactions on intestinal ion transport. / Tapper, E. J.; Powell, D. W.; Morris, S. M.

In: The American journal of physiology, Vol. 235, No. 4, 10.1978.

Research output: Contribution to journalArticle

Tapper, E. J. ; Powell, D. W. ; Morris, S. M. / Cholinergic-adrenergic interactions on intestinal ion transport. In: The American journal of physiology. 1978 ; Vol. 235, No. 4.
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