Chorioamnionitis - A complex pathophysiologic syndrome

R. Menon, R. N. Taylor, S. J. Fortunato

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Chorioamnionitis, inflammation of the amniochorionic membrane (fetal membranes) is a very common disease but a complex syndrome associated with pregnancy. It presents a clinical impasse due to lack of knowledge of specific etiologies associated with this condition making confident clinical interventions difficult. Recent reports provide insight into genetic, epigenetic, behavioral, psychosocial, molecular and pathophysiological factors that are associated with chorioamnionitis. However, a coordinated approach in understanding causality and lack of early indicators (clinical and biomarkers) has hampered gaining knowledge about the disease status preventing proper intervention. Several reviews have provided in-depth analysis of the histologic and clinical evidence associated with chorioamnionitis. In this review, we provide a novel perspective on chorioamnionitis based on recent evidences from scientific literature on inflammation, apoptosis and genetics.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalPlacenta
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

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Keywords

  • Apoptosis
  • Fetal membranes
  • Inflammation
  • Premature rupture of membranes
  • Prematurity
  • Preterm labor

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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