TY - JOUR
T1 - Chromatin dynamics in vivo
T2 - A game of musical chairs
AU - Melters, Daniël P.
AU - Nye, Jonathan
AU - Zhao, Haiqing
AU - Dalal, Yamini
N1 - Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2015/8/7
Y1 - 2015/8/7
N2 - Histones are a major component of chromatin, the nucleoprotein complex fundamental to regulating transcription, facilitating cell division, and maintaining genome integrity in almost all eukaryotes. In addition to canonical, replication-dependent histones, replication-independent histone variants exist in most eukaryotes. In recent years, steady progress has been made in understanding how histone variants assemble, their involvement in development, mitosis, transcription, and genome repair. In this review, we will focus on the localization of the major histone variants H3.3, CENP-A, H2A.Z, and macroH2A, as well as how these variants have evolved, their structural differences, and their functional significance in vivo.
AB - Histones are a major component of chromatin, the nucleoprotein complex fundamental to regulating transcription, facilitating cell division, and maintaining genome integrity in almost all eukaryotes. In addition to canonical, replication-dependent histones, replication-independent histone variants exist in most eukaryotes. In recent years, steady progress has been made in understanding how histone variants assemble, their involvement in development, mitosis, transcription, and genome repair. In this review, we will focus on the localization of the major histone variants H3.3, CENP-A, H2A.Z, and macroH2A, as well as how these variants have evolved, their structural differences, and their functional significance in vivo.
KW - CENP-A
KW - Chaperones
KW - Chromatin
KW - H2A.Z
KW - H3.3
KW - Histones
KW - macroH2A
UR - http://www.scopus.com/inward/record.url?scp=84940983863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940983863&partnerID=8YFLogxK
U2 - 10.3390/genes6030751
DO - 10.3390/genes6030751
M3 - Review article
AN - SCOPUS:84940983863
SN - 2073-4425
VL - 6
SP - 751
EP - 776
JO - Genes
JF - Genes
IS - 3
ER -