Chromatin dynamics in vivo: A game of musical chairs

Daniël P. Melters, Jonathan Nye, Haiqing Zhao, Yamini Dalal

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Histones are a major component of chromatin, the nucleoprotein complex fundamental to regulating transcription, facilitating cell division, and maintaining genome integrity in almost all eukaryotes. In addition to canonical, replication-dependent histones, replication-independent histone variants exist in most eukaryotes. In recent years, steady progress has been made in understanding how histone variants assemble, their involvement in development, mitosis, transcription, and genome repair. In this review, we will focus on the localization of the major histone variants H3.3, CENP-A, H2A.Z, and macroH2A, as well as how these variants have evolved, their structural differences, and their functional significance in vivo.

Original languageEnglish (US)
Pages (from-to)751-776
Number of pages26
JournalGenes
Volume6
Issue number3
DOIs
StatePublished - Aug 7 2015
Externally publishedYes

Keywords

  • CENP-A
  • Chaperones
  • Chromatin
  • H2A.Z
  • H3.3
  • Histones
  • macroH2A

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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