Chromatin organization by repetitive elements (CORE)

A genomic principle for the higher-order structure of chromosomes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Eukaryotic genomes contain a large amount of DNA repeats (also known as repetitive DNA, repetitive elements, and repetitive sequences). Here, I propose a role of repetitive DNA in the formation of higher-order structures of chromosomes. The central idea of this theory is that chromatin regions with repetitive sequences pair with regions harboring homologous repeats and that such somatic repeat pairing (RP) assembles repetitive DNA chromatin into compact chromosomal domains that specify chromatin folding in a site-directed manner. According to this theory, DNA repeats are not randomly distributed in the genome. Instead, they form a core framework that coordinates the architecture of chromosomes. In contrast to the viewpoint that DNA repeats are genomic 'junk', this theory advocates that repetitive sequences are chromatin organizer modules that determine chromatin-chromatin contact points within chromosomes. This novel concept, if correct, would suggest that DNA repeats in the linear genome encode a blueprint for higher-order chromosomal organization.

Original languageEnglish (US)
Pages (from-to)502-515
Number of pages14
JournalGenes
Volume2
Issue number3
DOIs
StatePublished - Sep 2011

Fingerprint

Chromosome Structures
Chromatin
DNA
Nucleic Acid Repetitive Sequences
Genome
Chromosomes

Keywords

  • Chromatin
  • Chromosome
  • DNA repeat
  • Repetitive DNA
  • Repetitive element
  • Repetitive sequence

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Chromatin organization by repetitive elements (CORE) : A genomic principle for the higher-order structure of chromosomes. / Tang, Shao-Jun.

In: Genes, Vol. 2, No. 3, 09.2011, p. 502-515.

Research output: Contribution to journalArticle

@article{4b1f098ec7bf4d669f86d61ef613cd7e,
title = "Chromatin organization by repetitive elements (CORE): A genomic principle for the higher-order structure of chromosomes",
abstract = "Eukaryotic genomes contain a large amount of DNA repeats (also known as repetitive DNA, repetitive elements, and repetitive sequences). Here, I propose a role of repetitive DNA in the formation of higher-order structures of chromosomes. The central idea of this theory is that chromatin regions with repetitive sequences pair with regions harboring homologous repeats and that such somatic repeat pairing (RP) assembles repetitive DNA chromatin into compact chromosomal domains that specify chromatin folding in a site-directed manner. According to this theory, DNA repeats are not randomly distributed in the genome. Instead, they form a core framework that coordinates the architecture of chromosomes. In contrast to the viewpoint that DNA repeats are genomic 'junk', this theory advocates that repetitive sequences are chromatin organizer modules that determine chromatin-chromatin contact points within chromosomes. This novel concept, if correct, would suggest that DNA repeats in the linear genome encode a blueprint for higher-order chromosomal organization.",
keywords = "Chromatin, Chromosome, DNA repeat, Repetitive DNA, Repetitive element, Repetitive sequence",
author = "Shao-Jun Tang",
year = "2011",
month = "9",
doi = "10.3390/genes2030502",
language = "English (US)",
volume = "2",
pages = "502--515",
journal = "Genes",
issn = "2073-4425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Chromatin organization by repetitive elements (CORE)

T2 - A genomic principle for the higher-order structure of chromosomes

AU - Tang, Shao-Jun

PY - 2011/9

Y1 - 2011/9

N2 - Eukaryotic genomes contain a large amount of DNA repeats (also known as repetitive DNA, repetitive elements, and repetitive sequences). Here, I propose a role of repetitive DNA in the formation of higher-order structures of chromosomes. The central idea of this theory is that chromatin regions with repetitive sequences pair with regions harboring homologous repeats and that such somatic repeat pairing (RP) assembles repetitive DNA chromatin into compact chromosomal domains that specify chromatin folding in a site-directed manner. According to this theory, DNA repeats are not randomly distributed in the genome. Instead, they form a core framework that coordinates the architecture of chromosomes. In contrast to the viewpoint that DNA repeats are genomic 'junk', this theory advocates that repetitive sequences are chromatin organizer modules that determine chromatin-chromatin contact points within chromosomes. This novel concept, if correct, would suggest that DNA repeats in the linear genome encode a blueprint for higher-order chromosomal organization.

AB - Eukaryotic genomes contain a large amount of DNA repeats (also known as repetitive DNA, repetitive elements, and repetitive sequences). Here, I propose a role of repetitive DNA in the formation of higher-order structures of chromosomes. The central idea of this theory is that chromatin regions with repetitive sequences pair with regions harboring homologous repeats and that such somatic repeat pairing (RP) assembles repetitive DNA chromatin into compact chromosomal domains that specify chromatin folding in a site-directed manner. According to this theory, DNA repeats are not randomly distributed in the genome. Instead, they form a core framework that coordinates the architecture of chromosomes. In contrast to the viewpoint that DNA repeats are genomic 'junk', this theory advocates that repetitive sequences are chromatin organizer modules that determine chromatin-chromatin contact points within chromosomes. This novel concept, if correct, would suggest that DNA repeats in the linear genome encode a blueprint for higher-order chromosomal organization.

KW - Chromatin

KW - Chromosome

KW - DNA repeat

KW - Repetitive DNA

KW - Repetitive element

KW - Repetitive sequence

UR - http://www.scopus.com/inward/record.url?scp=80053198150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053198150&partnerID=8YFLogxK

U2 - 10.3390/genes2030502

DO - 10.3390/genes2030502

M3 - Article

VL - 2

SP - 502

EP - 515

JO - Genes

JF - Genes

SN - 2073-4425

IS - 3

ER -