Chromosome aberrations in lymphocytes of mice after sub-acute low-level inhalation exposure to benzene

William W. Au, V-M Ramanujam, J. B. Ward, M. S. Legator

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Male and female CD-1 mice were exposed to near ambient air concentrations of benzene by inhalation for 22 h per day, 7 days per week for 6 weeks. The concentrations were 0, 40, 100 and 1000 ppb. Significant increases in chromosome aberrations in spleen lymphocytes were observed in exposed compared with control mice except in the high-dose group (p < 0.05 for female mice in 2 experiments and for male mice in 1 experiment; p < 0.15 for male mice in the second experiment). A lack of increase in aberrations among mice of the high-dose group may be due to an induction of detoxifying enzymes as observed by us in a previous study (Au et al., 1988b). We also found that the female mice were more sensitive to the clastogenic activity of benzene than male mice under our experimental conditions. Our study serves to emphasize the need to conduct subchronic, low-dose in vivo genotoxicity studies using exposure conditions similar to those of humans, for evaluation of potential hazards. Our data suggest that the current occupational exposure concentrations for benzene (< 1000 ppb) may still be hazardous to humans.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalMutation Research/Genetic Toxicology
Volume260
Issue number2
DOIs
StatePublished - 1991

Fingerprint

Inhalation Exposure
Lymphocytes
Chromosomes
Benzene
Aberrations
Chromosome Aberrations
Experiments
Hazards
Enzymes
Air
Enzyme Induction
Occupational Exposure
Inhalation
Spleen

Keywords

  • Benzene
  • Chromosome aberrations
  • Inhalation
  • Lymphocytes

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

Cite this

Chromosome aberrations in lymphocytes of mice after sub-acute low-level inhalation exposure to benzene. / Au, William W.; Ramanujam, V-M; Ward, J. B.; Legator, M. S.

In: Mutation Research/Genetic Toxicology, Vol. 260, No. 2, 1991, p. 219-224.

Research output: Contribution to journalArticle

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