Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding

Kathryn Cunningham, J. M. Paris, N. E. Goeders

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Repeated cocaine intoxication can result in the development of behavioral sensitization in animals and psychosis in humans, phenomena that have been associated with alterations in dopamine (DA) function. Using electrophysiologic and autoradiographic techniques, modifications of central serotonin (5-hydroxytryptamine; 5-HT) systems were investigated in rats treated with a regimen of cocaine administration that produced behavioral sensitization. The inhibitory response of single 5-HT neurons in the dorsal raphe (DR) to (-)-cocaine, the 5-HT uptake inhibitor fluoxetine or the 5- HT(1A) agonist 8-hydroxy-2-[di-N-propylamino]tetralin (8-OHDPAT) was significantly enhanced in cocaine-treated rats. Furthermore, several brain areas that contain either cell bodies (DR) or terminals for 5-HT (medial and sulcal prefrontal cortex, frontal cortex) showed cocaine-induced elevations in [3H]imipramine-labeled 5-HT uptake sites, while [3H]-8-OHDPAT-labeled 5- HT(1A) receptors were decreased only in the central medial amygdala. These results suggest that modifications of autoregulatory mechanisms secondary to alterations of 5-HT uptake processes may contribute to the development of cocaine sensitization.

Original languageEnglish (US)
Pages (from-to)112-123
Number of pages12
JournalSynapse
Volume11
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Cocaine
Serotonin
Homeostasis
8-Hydroxy-2-(di-n-propylamino)tetralin
Serotonin Receptor Agonists
Receptor, Serotonin, 5-HT1A
Imipramine
Fluoxetine
Serotonin Uptake Inhibitors
Frontal Lobe
Prefrontal Cortex
Psychotic Disorders
Dopamine
Neurons
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pharmacology

Cite this

Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding. / Cunningham, Kathryn; Paris, J. M.; Goeders, N. E.

In: Synapse, Vol. 11, No. 2, 1992, p. 112-123.

Research output: Contribution to journalArticle

Cunningham, Kathryn ; Paris, J. M. ; Goeders, N. E. / Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding. In: Synapse. 1992 ; Vol. 11, No. 2. pp. 112-123.
@article{ba3e7ffe8d8146b3b355e4fb65ddde4f,
title = "Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding",
abstract = "Repeated cocaine intoxication can result in the development of behavioral sensitization in animals and psychosis in humans, phenomena that have been associated with alterations in dopamine (DA) function. Using electrophysiologic and autoradiographic techniques, modifications of central serotonin (5-hydroxytryptamine; 5-HT) systems were investigated in rats treated with a regimen of cocaine administration that produced behavioral sensitization. The inhibitory response of single 5-HT neurons in the dorsal raphe (DR) to (-)-cocaine, the 5-HT uptake inhibitor fluoxetine or the 5- HT(1A) agonist 8-hydroxy-2-[di-N-propylamino]tetralin (8-OHDPAT) was significantly enhanced in cocaine-treated rats. Furthermore, several brain areas that contain either cell bodies (DR) or terminals for 5-HT (medial and sulcal prefrontal cortex, frontal cortex) showed cocaine-induced elevations in [3H]imipramine-labeled 5-HT uptake sites, while [3H]-8-OHDPAT-labeled 5- HT(1A) receptors were decreased only in the central medial amygdala. These results suggest that modifications of autoregulatory mechanisms secondary to alterations of 5-HT uptake processes may contribute to the development of cocaine sensitization.",
author = "Kathryn Cunningham and Paris, {J. M.} and Goeders, {N. E.}",
year = "1992",
doi = "10.1002/syn.890110204",
language = "English (US)",
volume = "11",
pages = "112--123",
journal = "Synapse",
issn = "0887-4476",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding

AU - Cunningham, Kathryn

AU - Paris, J. M.

AU - Goeders, N. E.

PY - 1992

Y1 - 1992

N2 - Repeated cocaine intoxication can result in the development of behavioral sensitization in animals and psychosis in humans, phenomena that have been associated with alterations in dopamine (DA) function. Using electrophysiologic and autoradiographic techniques, modifications of central serotonin (5-hydroxytryptamine; 5-HT) systems were investigated in rats treated with a regimen of cocaine administration that produced behavioral sensitization. The inhibitory response of single 5-HT neurons in the dorsal raphe (DR) to (-)-cocaine, the 5-HT uptake inhibitor fluoxetine or the 5- HT(1A) agonist 8-hydroxy-2-[di-N-propylamino]tetralin (8-OHDPAT) was significantly enhanced in cocaine-treated rats. Furthermore, several brain areas that contain either cell bodies (DR) or terminals for 5-HT (medial and sulcal prefrontal cortex, frontal cortex) showed cocaine-induced elevations in [3H]imipramine-labeled 5-HT uptake sites, while [3H]-8-OHDPAT-labeled 5- HT(1A) receptors were decreased only in the central medial amygdala. These results suggest that modifications of autoregulatory mechanisms secondary to alterations of 5-HT uptake processes may contribute to the development of cocaine sensitization.

AB - Repeated cocaine intoxication can result in the development of behavioral sensitization in animals and psychosis in humans, phenomena that have been associated with alterations in dopamine (DA) function. Using electrophysiologic and autoradiographic techniques, modifications of central serotonin (5-hydroxytryptamine; 5-HT) systems were investigated in rats treated with a regimen of cocaine administration that produced behavioral sensitization. The inhibitory response of single 5-HT neurons in the dorsal raphe (DR) to (-)-cocaine, the 5-HT uptake inhibitor fluoxetine or the 5- HT(1A) agonist 8-hydroxy-2-[di-N-propylamino]tetralin (8-OHDPAT) was significantly enhanced in cocaine-treated rats. Furthermore, several brain areas that contain either cell bodies (DR) or terminals for 5-HT (medial and sulcal prefrontal cortex, frontal cortex) showed cocaine-induced elevations in [3H]imipramine-labeled 5-HT uptake sites, while [3H]-8-OHDPAT-labeled 5- HT(1A) receptors were decreased only in the central medial amygdala. These results suggest that modifications of autoregulatory mechanisms secondary to alterations of 5-HT uptake processes may contribute to the development of cocaine sensitization.

UR - http://www.scopus.com/inward/record.url?scp=0026710951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026710951&partnerID=8YFLogxK

U2 - 10.1002/syn.890110204

DO - 10.1002/syn.890110204

M3 - Article

VL - 11

SP - 112

EP - 123

JO - Synapse

JF - Synapse

SN - 0887-4476

IS - 2

ER -