Chronic cocaine treatment impairs the regulation of synaptosomal 3H-DA release by D2 autoreceptors

Su Jin Yi, Kenneth M. Johnson

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The effect of repeated administration of cocaine on presynaptic D2 autoreceptor sensitivity in synaptosomes was studied. In rats treated chronically with saline, the dopamine D2 agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin (N-0437) caused a significant inhibition of the Ca2+-evoked 3H-DA release from synaptosomes prepared from the nucleus accumbens and from the striatum; this effect was blocked by the D2 antagonist sulpiride. However, chronic cocaine pretreatment abolished the effect of N-0437 in both areas, suggesting a subsensitivity of release-modulating terminal DA autoreceptors. Subsensitive DA autoreceptors would enhance stimulated DA release from mesolimbic and nigrostriatal terminals and may play a role in the behavioral sensitization observed in this paradigm.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume36
Issue number3
DOIs
StatePublished - 1990

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Autoreceptors
Cocaine
Synaptosomes
Sulpiride
Dopamine Agonists
Nucleus Accumbens
Rats
Dopamine
N 0437

Keywords

  • Behavioral sensitization
  • Chronic cocaine
  • DA autoreceptor
  • DA release

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Chronic cocaine treatment impairs the regulation of synaptosomal 3H-DA release by D2 autoreceptors. / Yi, Su Jin; Johnson, Kenneth M.

In: Pharmacology, Biochemistry and Behavior, Vol. 36, No. 3, 1990, p. 457-461.

Research output: Contribution to journalArticle

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