Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice

Ping Cai, Rolf König, Paul J. Boor, Shakuntala Kondraganti, Bhupendra Kaphalia, M Khan, Ghulam Ansari

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Trichloroethene (TCE) exacerbates the development of autoimmune responses in autoimmune-prone MRL +/+ mice. Although TCE-mediated autoimmune responses are associated with an increase in serum immunoglobulins and autoantibodies, the underlying mechanism of autoimmunity is not known. To determine the progression of TCE-mediated immunotoxicity, female MRL +/+ mice were chronically exposed to TCE through the drinking water (0.5 mg/ml of TCE) for various periods of time. Serum concentrations of antinuclear antibodies increased after 36 and 48 weeks of TCE exposure. Histopathological analyses showed lymphocyte infiltration in the livers of MRL +/+ mice exposed to TCE for 36 or 48 weeks. Lymphocyte infiltration was also apparent in the pancreas, lungs, and kidneys of mice exposed to TCE for 48 weeks. Immunoglobulin deposits in kidney glomeruli were found after 48 weeks of exposure to TCE. Our results suggest that chronic exposure to TCE promotes inflammation in the liver, pancreas, lungs, and kidneys, which may lead to SLE-like disease in MRL +/+ mice.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalToxicology and Applied Pharmacology
Volume228
Issue number1
DOIs
StatePublished - Apr 1 2008

Fingerprint

Trichloroethylene
Autoimmunity
Lymphocytes
Infiltration
Liver
Immunoglobulins
Pancreas
Kidney Glomerulus
Kidney
Lung
Antinuclear Antibodies
Serum
Drinking Water
Autoantibodies
Deposits
Inflammation

Keywords

  • Autoimmunity
  • Cytokines
  • Hepatitis
  • Immunotoxicity
  • MRL +/+ mice
  • Trichloroethene (TCE)

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice. / Cai, Ping; König, Rolf; Boor, Paul J.; Kondraganti, Shakuntala; Kaphalia, Bhupendra; Khan, M; Ansari, Ghulam.

In: Toxicology and Applied Pharmacology, Vol. 228, No. 1, 01.04.2008, p. 68-75.

Research output: Contribution to journalArticle

@article{66c5da29c719411dab7358b4b0e7035d,
title = "Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice",
abstract = "Trichloroethene (TCE) exacerbates the development of autoimmune responses in autoimmune-prone MRL +/+ mice. Although TCE-mediated autoimmune responses are associated with an increase in serum immunoglobulins and autoantibodies, the underlying mechanism of autoimmunity is not known. To determine the progression of TCE-mediated immunotoxicity, female MRL +/+ mice were chronically exposed to TCE through the drinking water (0.5 mg/ml of TCE) for various periods of time. Serum concentrations of antinuclear antibodies increased after 36 and 48 weeks of TCE exposure. Histopathological analyses showed lymphocyte infiltration in the livers of MRL +/+ mice exposed to TCE for 36 or 48 weeks. Lymphocyte infiltration was also apparent in the pancreas, lungs, and kidneys of mice exposed to TCE for 48 weeks. Immunoglobulin deposits in kidney glomeruli were found after 48 weeks of exposure to TCE. Our results suggest that chronic exposure to TCE promotes inflammation in the liver, pancreas, lungs, and kidneys, which may lead to SLE-like disease in MRL +/+ mice.",
keywords = "Autoimmunity, Cytokines, Hepatitis, Immunotoxicity, MRL +/+ mice, Trichloroethene (TCE)",
author = "Ping Cai and Rolf K{\"o}nig and Boor, {Paul J.} and Shakuntala Kondraganti and Bhupendra Kaphalia and M Khan and Ghulam Ansari",
year = "2008",
month = "4",
day = "1",
doi = "10.1016/j.taap.2007.11.031",
language = "English (US)",
volume = "228",
pages = "68--75",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice

AU - Cai, Ping

AU - König, Rolf

AU - Boor, Paul J.

AU - Kondraganti, Shakuntala

AU - Kaphalia, Bhupendra

AU - Khan, M

AU - Ansari, Ghulam

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Trichloroethene (TCE) exacerbates the development of autoimmune responses in autoimmune-prone MRL +/+ mice. Although TCE-mediated autoimmune responses are associated with an increase in serum immunoglobulins and autoantibodies, the underlying mechanism of autoimmunity is not known. To determine the progression of TCE-mediated immunotoxicity, female MRL +/+ mice were chronically exposed to TCE through the drinking water (0.5 mg/ml of TCE) for various periods of time. Serum concentrations of antinuclear antibodies increased after 36 and 48 weeks of TCE exposure. Histopathological analyses showed lymphocyte infiltration in the livers of MRL +/+ mice exposed to TCE for 36 or 48 weeks. Lymphocyte infiltration was also apparent in the pancreas, lungs, and kidneys of mice exposed to TCE for 48 weeks. Immunoglobulin deposits in kidney glomeruli were found after 48 weeks of exposure to TCE. Our results suggest that chronic exposure to TCE promotes inflammation in the liver, pancreas, lungs, and kidneys, which may lead to SLE-like disease in MRL +/+ mice.

AB - Trichloroethene (TCE) exacerbates the development of autoimmune responses in autoimmune-prone MRL +/+ mice. Although TCE-mediated autoimmune responses are associated with an increase in serum immunoglobulins and autoantibodies, the underlying mechanism of autoimmunity is not known. To determine the progression of TCE-mediated immunotoxicity, female MRL +/+ mice were chronically exposed to TCE through the drinking water (0.5 mg/ml of TCE) for various periods of time. Serum concentrations of antinuclear antibodies increased after 36 and 48 weeks of TCE exposure. Histopathological analyses showed lymphocyte infiltration in the livers of MRL +/+ mice exposed to TCE for 36 or 48 weeks. Lymphocyte infiltration was also apparent in the pancreas, lungs, and kidneys of mice exposed to TCE for 48 weeks. Immunoglobulin deposits in kidney glomeruli were found after 48 weeks of exposure to TCE. Our results suggest that chronic exposure to TCE promotes inflammation in the liver, pancreas, lungs, and kidneys, which may lead to SLE-like disease in MRL +/+ mice.

KW - Autoimmunity

KW - Cytokines

KW - Hepatitis

KW - Immunotoxicity

KW - MRL +/+ mice

KW - Trichloroethene (TCE)

UR - http://www.scopus.com/inward/record.url?scp=40849126568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40849126568&partnerID=8YFLogxK

U2 - 10.1016/j.taap.2007.11.031

DO - 10.1016/j.taap.2007.11.031

M3 - Article

C2 - 18234256

AN - SCOPUS:40849126568

VL - 228

SP - 68

EP - 75

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 1

ER -