Chronic granulomatous disease involving the central nervous system

David Walker, Gretchen Okiye

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Two male sibling infants died following a short course of lethargy and obtundation after a lifelong history of persistent, unrelenting diarrhea. Postmortem examination revealed extensive necrosis and early granuloma formation in the liver, spleen, lungs, and lymph nodes as well as in the central nervous system. To our knowledge, this fulminant clinical course, with documentation of granulomatous CNS lesions, has not been reported in patients with chronic granulomatous disease of childhood..

Original languageEnglish (US)
Pages (from-to)159-167
Number of pages9
JournalFetal and Pediatric Pathology
Volume1
Issue number2
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Chronic Granulomatous Disease
Lethargy
Granuloma
Documentation
Siblings
Autopsy
Diarrhea
Necrosis
Spleen
Central Nervous System
Lymph Nodes
Lung
Liver

Keywords

  • Central nervous system
  • Choroid plexus
  • Chronic granulomatous disease
  • Granuloma
  • Meningoencephalitis
  • Phagocyte

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Chronic granulomatous disease involving the central nervous system. / Walker, David; Okiye, Gretchen.

In: Fetal and Pediatric Pathology, Vol. 1, No. 2, 1983, p. 159-167.

Research output: Contribution to journalArticle

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