Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus)

Marina T. Siirin, Tao Duan, Hao Lei, Hilda Guzman, Amelia P A Travassos Da Rosa, Douglas M. Watts, Shu Yuan Xiao, Robert B. Tesh

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To further study the phenomenon of flavivirus persistent infection, golden hamsters (Mesocricetus auratus) were inoculated intraperitoneally with a low pathogenicity strain of St. Louis encephalitis virus (SLEV). After inoculation, the animals remained asymptomatic and developed high levels of specific neutralizing antibodies in their sera. However, about one half of the hamsters continued to shed infectious SLEV in their urine for prolonged periods of time. By co-cultivation, SLEV was recovered from selected tissues (kidney, lung, and brain) of some of the animals for up to 185 days after initial infection. Although no specific histopathologic changes were observed in these tissues, SLEV antigen was shown by immunohistochemistry in the interstitium and tubular epithelium of the renal cortex and in a few large neurons of the cerebral cortex. Seventeen SLEV isolates from urine and tissues of the chronically infected hamsters were sequenced. In comparison with the infecting parent SLEV strain, two common mutations and amino acid substitutions were observed in all of the hamster isolates. The findings of this study were very similar to previous descriptions of chronic West Nile, Modoc, and tick-borne encephalitis virus infections in mammals, and they re-emphasize the potential importance of persistent flavivirus infection in vertebrates.

Original languageEnglish (US)
Pages (from-to)299-306
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number2
StatePublished - Feb 2007

Fingerprint

St. Louis Encephalitis Viruses
Mesocricetus
Virus Diseases
Flavivirus Infections
Cricetinae
Urine
Tick-Borne Encephalitis Viruses
Kidney
Amino Acid Substitution
Neutralizing Antibodies
Cerebral Cortex
Virulence
Vertebrates
Infectious Encephalitis
Mammals
Epithelium
Immunohistochemistry
Neurons
Antigens
Lung

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Siirin, M. T., Duan, T., Lei, H., Guzman, H., Travassos Da Rosa, A. P. A., Watts, D. M., ... Tesh, R. B. (2007). Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). American Journal of Tropical Medicine and Hygiene, 76(2), 299-306.

Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). / Siirin, Marina T.; Duan, Tao; Lei, Hao; Guzman, Hilda; Travassos Da Rosa, Amelia P A; Watts, Douglas M.; Xiao, Shu Yuan; Tesh, Robert B.

In: American Journal of Tropical Medicine and Hygiene, Vol. 76, No. 2, 02.2007, p. 299-306.

Research output: Contribution to journalArticle

Siirin, MT, Duan, T, Lei, H, Guzman, H, Travassos Da Rosa, APA, Watts, DM, Xiao, SY & Tesh, RB 2007, 'Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus)', American Journal of Tropical Medicine and Hygiene, vol. 76, no. 2, pp. 299-306.
Siirin MT, Duan T, Lei H, Guzman H, Travassos Da Rosa APA, Watts DM et al. Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). American Journal of Tropical Medicine and Hygiene. 2007 Feb;76(2):299-306.
Siirin, Marina T. ; Duan, Tao ; Lei, Hao ; Guzman, Hilda ; Travassos Da Rosa, Amelia P A ; Watts, Douglas M. ; Xiao, Shu Yuan ; Tesh, Robert B. / Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). In: American Journal of Tropical Medicine and Hygiene. 2007 ; Vol. 76, No. 2. pp. 299-306.
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