Chronological and spatial analysis of the 1996 Ebola Reston virus outbreak in a monkey breeding facility in the Philippines

Mary Elizabeth G Miranda, Yasuhiro Yoshikawa, Daria L. Manalo, Alan B. Calaor, Noel Lee J Miranda, Fumiaki Cho, Tetsuro Ikegami, Thomas Ksiazek

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To describe the transmission pattern of natural infection with Ebola Reston (EBO-R) virus in a breeding colony, the chronological and spatial analysis of mortality during the 1996 EBO-R virus outbreak was done in this study. The EBO-R virus infection among monkeys in the facility was widespread. Over a period of 3 months, 14 out of 21 occupied units were contaminated with antigen positive animals. A large number of wild-caught monkeys were involved in this outbreak suggesting that wild-caught monkeys have a high susceptibility to EBO-R virus infection. In this outbreak, morbidity patterns for individual animal units were very different regardless of the type and size of cages, individual or gang cages. The results suggest that not only the cage size but also poor animal husbandry practices may be risk factors for the spread of EBO-R infection.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalExperimental Animals
Volume51
Issue number2
DOIs
StatePublished - Apr 2002
Externally publishedYes

Fingerprint

Reston Ebola virus
Ebola Hemorrhagic Fever
Ebolavirus
Spatial Analysis
Philippines
Viruses
Breeding
Haplorhini
monkeys
Disease Outbreaks
cage size
breeding
Animals
infection
Animal Husbandry
animal husbandry
Morbidity
morbidity
Antigens
animals

Keywords

  • Cynomolgus monkey
  • Ebola Reston virus
  • Epidemiology

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Chronological and spatial analysis of the 1996 Ebola Reston virus outbreak in a monkey breeding facility in the Philippines. / Miranda, Mary Elizabeth G; Yoshikawa, Yasuhiro; Manalo, Daria L.; Calaor, Alan B.; Miranda, Noel Lee J; Cho, Fumiaki; Ikegami, Tetsuro; Ksiazek, Thomas.

In: Experimental Animals, Vol. 51, No. 2, 04.2002, p. 173-179.

Research output: Contribution to journalArticle

Miranda, Mary Elizabeth G ; Yoshikawa, Yasuhiro ; Manalo, Daria L. ; Calaor, Alan B. ; Miranda, Noel Lee J ; Cho, Fumiaki ; Ikegami, Tetsuro ; Ksiazek, Thomas. / Chronological and spatial analysis of the 1996 Ebola Reston virus outbreak in a monkey breeding facility in the Philippines. In: Experimental Animals. 2002 ; Vol. 51, No. 2. pp. 173-179.
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