Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder

Liangsuo Ma, Joel L. Steinberg, James M. Bjork, Brian A. Taylor, Albert J. Arias, Mishka Terplan, Noelle Anastasio, Edward A. Zuniga, Michael Lennon, Kathryn Cunningham, F. Gerard Moeller

Research output: Contribution to journalArticle

Abstract

Individuals with opioid use disorder (OUD) often relapse when exposed to opioid-related cues. Previous functional magnetic resonance imaging (fMRI) studies have identified neuronal corticolimbic changes related to drug cue reactivity in OUD. However, the corresponding manner in which brain regions interact is still unclear. Effective (directional) connectivity was analyzed using dynamic causal modeling of fMRI data acquired from 27 OUD participants (13 with OUD and 14 with OUD and cocaine use disorder [OUD+CUD]), while performing an opioid-word Stroop task. Participants were shown opioid and neutral words presented in different colors and were instructed to indicate word color but ignore word meaning. The effects of opioid words relative to neutral words on effective connectivity and on behavioral reaction time were defined as modulatory change and attentional bias, respectively. For all the 27 participants, left anterior cingulate cortex (ACC) to right hippocampus effective connectivity exhibited the largest modulatory change, which was positively correlated with attentional bias. The findings for the ACC to hippocampus EC were consistent across OUD and CUD found in a previous study.

Original languageEnglish (US)
JournalPsychiatry Research - Neuroimaging
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Opioid Analgesics
Cues
Pharmaceutical Preparations
Gyrus Cinguli
Hippocampus
Attentional Bias
Color
Magnetic Resonance Imaging
Cocaine
Reaction Time
Recurrence
Brain

Keywords

  • Attentional bias
  • Cue reactivity
  • Dynamic causal modeling
  • Effective connectivity
  • Opioid use disorder

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder. / Ma, Liangsuo; Steinberg, Joel L.; Bjork, James M.; Taylor, Brian A.; Arias, Albert J.; Terplan, Mishka; Anastasio, Noelle; Zuniga, Edward A.; Lennon, Michael; Cunningham, Kathryn; Moeller, F. Gerard.

In: Psychiatry Research - Neuroimaging, 01.01.2019.

Research output: Contribution to journalArticle

Ma, Liangsuo ; Steinberg, Joel L. ; Bjork, James M. ; Taylor, Brian A. ; Arias, Albert J. ; Terplan, Mishka ; Anastasio, Noelle ; Zuniga, Edward A. ; Lennon, Michael ; Cunningham, Kathryn ; Moeller, F. Gerard. / Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder. In: Psychiatry Research - Neuroimaging. 2019.
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