Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro

Charles A. Kasal, Michael Menaker, J. Regino Perez-Polo

    Research output: Contribution to journalArticlepeer-review

    126 Scopus citations

    Abstract

    N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm ofenzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.

    Original languageEnglish (US)
    Pages (from-to)656-658
    Number of pages3
    JournalScience
    Volume203
    Issue number4381
    DOIs
    StatePublished - Jan 1 1979

    ASJC Scopus subject areas

    • General

    Fingerprint Dive into the research topics of 'Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro'. Together they form a unique fingerprint.

    Cite this