Circadian clock in culture

N-acetyltransferase activity of chick pineal glands oscillates in vitro

Charles A. Kasal, Michael Menaker, J. Regino Perez-Polo

    Research output: Contribution to journalArticle

    127 Citations (Scopus)

    Abstract

    N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm ofenzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.

    Original languageEnglish (US)
    Pages (from-to)656-658
    Number of pages3
    JournalScience
    Volume203
    Issue number4381
    StatePublished - 1979

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    Circadian Clocks
    Acetyltransferases
    Pineal Gland
    Circadian Rhythm
    In Vitro Techniques

    ASJC Scopus subject areas

    • General

    Cite this

    Kasal, C. A., Menaker, M., & Perez-Polo, J. R. (1979). Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro. Science, 203(4381), 656-658.

    Circadian clock in culture : N-acetyltransferase activity of chick pineal glands oscillates in vitro. / Kasal, Charles A.; Menaker, Michael; Perez-Polo, J. Regino.

    In: Science, Vol. 203, No. 4381, 1979, p. 656-658.

    Research output: Contribution to journalArticle

    Kasal, CA, Menaker, M & Perez-Polo, JR 1979, 'Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro', Science, vol. 203, no. 4381, pp. 656-658.
    Kasal, Charles A. ; Menaker, Michael ; Perez-Polo, J. Regino. / Circadian clock in culture : N-acetyltransferase activity of chick pineal glands oscillates in vitro. In: Science. 1979 ; Vol. 203, No. 4381. pp. 656-658.
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