Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro

Charles A. Kasal; Michael Menaker; J. Regino Perez-Polo

doi:10.1126/science.569904

Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro

Charles A. Kasal, Michael Menaker, J. Regino Perez-Polo

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127 Scopus citations

Abstract

N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm ofenzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.

Original language	English (US)
Pages (from-to)	656-658
Number of pages	3
Journal	Science
Volume	203
Issue number	4381
DOIs	https://doi.org/10.1126/science.569904
State	Published - 1979

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title = "Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro",

abstract = "N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm ofenzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.",

author = "Kasal, {Charles A.} and Michael Menaker and Perez-Polo, {J. Regino}",

year = "1979",

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AU - Menaker, Michael

AU - Perez-Polo, J. Regino

PY - 1979

Y1 - 1979

N2 - N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm ofenzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.

AB - N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm ofenzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.

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Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro

Abstract

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