Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro

Charles A. Kasal, Michael Menaker, J. Regino Perez-Polo

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

N-Acetyltransferase activity was measured in organ-cultured chick pineal glands. A circadian rhythm ofenzyme activity persisted in cultured glands for up to 4 days. The phase of the rhythm in vitro closely approximates its phase in vivo. These observations demonstrate that the pineal gland of chicks contains (or is) a self-sustained circadian oscillator.

Original languageEnglish (US)
Pages (from-to)656-658
Number of pages3
JournalScience
Volume203
Issue number4381
DOIs
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro'. Together they form a unique fingerprint.

Cite this